Reference |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
Gill M, 1997 |
|
480 bp |
HRR P=0.014 (df=1) for allele 480 bp
HRR P=0.014 (df=1) for allele 480 bp
|
HRR analysis revealed a significant association between ADHD......
HRR analysis revealed a significant association between ADHD and the 480-bp DAT1 allele. The 480-bp allele was preferentially transmitted to ADHD probands.
More...
|
Significant
|
Holmes J, 2000 |
5, 8-11 repeats |
10-repeat |
Case-control analysis: overall P-value=0.82; TDT analysis: o......
Case-control analysis: overall P-value=0.82; TDT analysis: overall P-value=0.75
More...
|
no evidence of association with SLC6A3 using either TDT or c......
no evidence of association with SLC6A3 using either TDT or case control analysis
More...
|
Non-significant
|
Waldman ID, 1998 |
3-11 repeats |
10R |
Between-family association t-test: one-tailed P=0.032 for HI......
Between-family association t-test: one-tailed P=0.032 for HI symptoms, one-tailed P=0.137 for IA symptoms; Within-family analyses using genetically discordant siblings: Wilcoxon signed ranks test one-tailed P=0.008 for HI symptoms, one-tailed P=0.011 for IA symptoms; Within-family TDT test by ADHD diagnosis,severity level, and genetic model: P=0.0349 for any diagnosis at medium level of symptom severity, P=0.0106 for any diagnosis at high level of severity, P=0.0374 for combined tyep at low level of severity, P=0.0163 for combined tyep at medium level of severity, P=0.0325 for combined tyep at high level of severity, P=0.0387 for combined tyep at medium level of severity under recessive model.
More...
|
Within-family analyses of LD confirmed the 480-bp allele (10......
Within-family analyses of LD confirmed the 480-bp allele (10-repeat) as the high-risk allele. In between-family association analyses, levels of HI symptoms but not IA symptoms were related to the number of DAT1 high-risk alleles. Siblings discordant for the number of DAT1 high-risk alleles differed markedly in their levels of both HI and IA symptoms. Within-family analyses of LD, using the TDT, suggested association and linkage of ADHD with DAT1 and that this relation was especially strong with the combined but not the inattentive subtype. The relation of DAT1 to ADHD increased monotonically, from low to medium to high levels of symptom severity.
More...
|
Significant
|
Curran S, 2001 |
|
480bp allele |
TDT P-value=0.013, X2=6.119, OR=1.95 in the UK sa......
TDT P-value=0.013, X2=6.119, OR=1.95 in the UK sample; TDT P-value=0.335, X2=0.931, OR=0.81 in the Turkish sample; TDT P-value=0.063, X2=3.47, OR=1.16 in the combined analysis
More...
|
when considered alone, data from the UK sample but not the T......
when considered alone, data from the UK sample but not the Turkish sample supported association and linkage between the SLC6A3 locus and ADHD, and in the combined analysis, they find only a marginal change in overall significance
More...
|
Significant
|
Barr CL, 2001(a) |
200-520bp |
|
allelic TDT two-sided P-value=0.110, one-sided P-value=0.055......
allelic TDT two-sided P-value=0.110, one-sided P-value=0.055, X2=2.56 for 480bp, allelic TDT two-sided P-value=0.123, one-sided P-value=0.064, X2=2.32 for 440bp
More...
|
the TDT was not significant for any allele of the polymorphi......
the TDT was not significant for any allele of the polymorphism, but there was a trend for the biased transmission of the 480bp allele of the VNTR to the ADHD probands
More...
|
Non-significant
|
Todd RD, 2001(a) |
|
|
ETDT P-value=1.00, X2(3df)=0.06 in DSM-IV inatten......
ETDT P-value=1.00, X2(3df)=0.06 in DSM-IV inattentive, ETDT P-value=0.23, X2(2df)=3.0 in DSM-IV combined, ETDT P-value=0.76, X2(1df)=0.09 in DSM-IV hyperactive, ETDT P-value=0.71, X2(3df)=1.4 in DSM-IV any ADHD; allele-wise P-value=0.28, corrected P-value=0.48, X2=1.18 for 10 repeat, allele-wise P-value=0.31, corrected P-value=0.52, X2=1.034 for 9 repeat in DSM-IV any ADHD; allele-wise P-value=0.16, corrected P-value=0.29, X2=1.976 for 10 repeat, allele-wise P-value=0.21, corrected P-value=0.37, X2=1.60 for 9 repeat in DSM-IV combined; allele-wise P-value=0.81, corrected P-value=0.97, X2=0.056 for 10 repeat, allele-wise P-value=0.81, corrected P-value=0.96, X2=0.059 for 9 repeat in DSM-IV inattentive; allele-wise P-value=0.76, corrected P-value=0.94, X2=0.091 for 10 repeat, allele-wise P-value=0.76, corrected P-value=0.94, X2=0.091 for 9 repeat in DSM-IV hyperactive/impulsive
More...
|
there was no significant transmission distortion for the SLC......
there was no significant transmission distortion for the SLC6A3 3' VNTR for any definition of ADHD and there was no significant allele-wise evidence for transmission distortion for any ADHD subtype for both the 10-repeat and 9-repeat alleles
More...
|
Non-significant
|
Roman T, 2001 |
|
10R |
allelic HRR P-value=0.88, X2=0.02 in the total sa......
allelic HRR P-value=0.88, X2=0.02 in the total sample, allelic HRR P-value=0.87, X2=0.02 in the combined type for 10R; allele frequencies chi-square between probands and controls =1.90, P-value=0.86, chi-square between parents and controls=6.52, P-value=0.39; P-value=0.41, X2=0.68 for other allele
More...
|
no preferential transmission for either the 10-repeat allele......
no preferential transmission for either the 10-repeat allele or other alleles was observed
More...
|
Non-significant
|
Maher BS, 2002 |
|
|
P-value=0.06, pooled OR=1.27; test of homogeneity P-value=0.......
P-value=0.06, pooled OR=1.27; test of homogeneity P-value=0.37, Q=10.85, df=10
More...
|
no positive association was demostrated with ADHD in the met......
no positive association was demostrated with ADHD in the meta-analysis
More...
|
Non-significant
|
Kirley A, 2002 |
|
480bp |
HHRR: P-value=0.0062 (RR=1.4, OR=1.88); TDT: P-value=0.042 (......
HHRR: P-value=0.0062 (RR=1.4, OR=1.88); TDT: P-value=0.042 (OR=1.63); TDT by presence of family history: P-value=0.494 (OR[95%CI]=1.87[0.47-7.35]); TDT of Paternal and Maternal transmissions: P-value=0.403 (OR[95%CI]=1.56[0.55-4.44])
More...
|
Significant preferential transmission
Significant preferential transmission
|
Significant
|
Smith KM, 2003 |
|
10R |
Genotype groupings chi-square P-value=0.840, Allele grouping......
Genotype groupings chi-square P-value=0.840, Allele groupings chi-square P-value=0.740
More...
|
no significant differences were observed
no significant differences were observed
|
Non-significant
|
Hawi Z, 2003 |
|
|
Global X2=0.02; HHRR P-value=0.56, X2=......
Global X2=0.02; HHRR P-value=0.56, X2=0.34, RR=0.66 for allele1; HHRR P-value=0.0062, X2=7.5, RR=1.4 for allele2
More...
|
significant association between allele 2 (480 bp) of the SLC......
significant association between allele 2 (480 bp) of the SLC6A3 VNTR polymorphism and ADHD was reported
More...
|
Significant
|
Kustanovich V, 2004 |
|
|
GRR=1.39, TDT P-value=0.484
GRR=1.39, TDT P-value=0.484
|
No evidence for an association was found
No evidence for an association was found
|
Non-significant
|
Chen CK, 2003 |
|
10R |
TDT P-value=0.001, X2(1.df)=10.8, OR=2.9
TDT P-value=0.001, X2(1.df)=10.8, OR=2.9
|
found evidence of increased transmission of the 10-repeat al......
found evidence of increased transmission of the 10-repeat allele
More...
|
Significant
|
Bakker SC, 2005 |
|
10R |
allelic TDT P-value=0.73
allelic TDT P-value=0.73
|
no signs of a distorted transmissions of any of the single p......
no signs of a distorted transmissions of any of the single polymorphisms, or of single alleles
More...
|
Non-significant
|
Qian Q, 2004 |
short(6-7R)/long(9-12R) |
|
case-control genotype X2 test: P-value=0.032 (OR=......
case-control genotype X2 test: P-value=0.032 (OR=2.068, 95%CI=1.050-4.070) for ADHD, P-value=0.014 (OR=2.529, 95%CI=1.178-5.431) for ADHD-C, P-value=0.029 (OR=2.488, 95% CI=1.074-5.764) for pure-ADHD; case-control allele X2 test: P-value=0.037 (OR=2.006, 96%CI=1.032-3.901) for ADHD, P-value=0.017 (OR=2.423, 95%CI=1.148-5.112) for ADHD-C, P-value=0.032 (OR=2.386, 95%CI=1.052-5.414) for pure-ADHD; HHRR P-value=0.411; ETDT P-value>0.05
More...
|
long-repeat genotypes and alleles were seen more frequently ......
long-repeat genotypes and alleles were seen more frequently in ADHD probands than in controls; no overall evidence of association between SLC6A31 and ADHD according to HHRR analysis; no preferential transmission of any allele were found by ETDT test.
More...
|
Significant
|
Ouellet-Morin I, 2008 |
9/10 allele |
|
QTDT P-value>0.05 in AP, AT, AO models at 6 and 7 years old
QTDT P-value>0.05 in AP, AT, AO models at 6 and 7 years old
|
no significant association
no significant association
|
Non-significant
|
Johansson S, 2008 |
|
|
Overall P-value=0.48; allelic P-value=0.59, OR=0.94
Overall P-value=0.48; allelic P-value=0.59, OR=0.94
|
showed no association
showed no association
|
Non-significant
|
Nyman ES, 2007 |
|
|
No available information.
No available information.
|
No evidence of association was seen.
No evidence of association was seen.
|
Non-significant
|
Banoei MM, 2008 |
|
|
chi-square P-value=0.9, X2=0.081
chi-square P-value=0.9, X2=0.081
|
no association between 10-allele and ADHD
no association between 10-allele and ADHD
|
Non-significant
|
Yang B, 2007 |
|
|
Meta-Analysis: TDT P-value=0.004, OR=1.17, 95%CI=1.05-1.30; ......
Meta-Analysis: TDT P-value=0.004, OR=1.17, 95%CI=1.05-1.30; HHRR P-value=0.07, OR=1.50, 95%CI=0.97-2.33; Case-Control P-value=0.54, OR=0.95, 95%CI=0.80-1.12
More...
|
There were statistically significant evidences for heterogen......
There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies, but not in case-control studies.
More...
|
Significant
|
Das M, 2007 |
9-, 10-repeat |
|
9-repeat allele: HHRR P-value=0.009, OR=2.3; TDT P-value=0.0......
9-repeat allele: HHRR P-value=0.009, OR=2.3; TDT P-value=0.002, RR=3.11; FBAT P-value=0.019. 10-repeat allele: FBAT P-value=0.032.
More...
|
The observed transmission of the 9R allele deviated signific......
The observed transmission of the 9R allele deviated significantly from that of the expected transmission.
More...
|
Significant
|
Bruggemann D, 2007 |
|
|
no P-value
no P-value
|
no association was found when testing single markers
no association was found when testing single markers
|
Non-significant
|
Asherson P, 2007 |
|
|
TDT P-value=0.0186 for 3'UTR VNTR; 10R: TDT P-value=0.010, O......
TDT P-value=0.0186 for 3'UTR VNTR; 10R: TDT P-value=0.010, OR=0.21; 9R: TDT P-value=0.005, OR=0.81
More...
|
global evidence for association with the 3'UTR VNTR; 9R and ......
global evidence for association with the 3'UTR VNTR; 9R and 10R were associated with risk for ADHD
More...
|
Significant
|
Franke B, 2010 |
|
|
9/9 genotype P-value=0.005, OR=1.5, X2 (1df)=8.15......
9/9 genotype P-value=0.005, OR=1.5, X2 (1df)=8.15, meta-analysis P-value=0.03, OR=1.34; 10/10 genotype meta-analysis P-value=0.29, OR=0.93
More...
|
the 9/9 genotype of the 3'-UTR VNTR showed association with ......
the 9/9 genotype of the 3'-UTR VNTR showed association with the disorder in adults in the combined and meta-analysis
More...
|
Significant
|
Gizer IR, 2009 |
|
|
Meta-analysis model: Random: OR=1.12, 95% CI=1.00-1.27, P-va......
Meta-analysis model: Random: OR=1.12, 95% CI=1.00-1.27, P-value=0.028; Q-statistic: P-value=0.000001, I2=65
More...
|
significant but modest association
significant but modest association
|
Significant
|
Niederhofer H, 2008 |
|
6R |
HRR P-value=0.00, OR=1.0, X2=0.00; allelic TDT X<......
HRR P-value=0.00, OR=1.0, X2=0.00; allelic TDT X2=0.00, OR=1.0 in 36 trios. HRR OR=0.91, X2=0.04; allelic X2=0.17, OR=0.88 in 36 trios and 13 duos
More...
|
none of the alleles was significantly associated with ADHD n......
none of the alleles was significantly associated with ADHD neither by HRR nor TDT; a nonsignificant result was obtained by both HRR and TDT for the risk allele (6R)
More...
|
Non-significant
|
Franke B, 2008 |
|
|
Pearson chi-square P-value=0.085, OR=1 for 10/10 genotype fr......
Pearson chi-square P-value=0.085, OR=1 for 10/10 genotype frequency, OR=1.27 for 10/9 genotype frequency, OR=1.98 for 9/9 genotype frequency
More...
|
genotype analysis did not show significant differences betwe......
genotype analysis did not show significant differences between cases and controls
More...
|
Non-significant
|
Genro JP, 2008 |
9/10 repeats |
|
9 repeat P-value=0.867 for total sample, P-value=0.458 for c......
9 repeat P-value=0.867 for total sample, P-value=0.458 for combined sample; 10 repeat P-value=0.873 for total sample; P-value=0.365 for combined sample
More...
|
no allele was significantly more transmitted than expected
no allele was significantly more transmitted than expected
|
Non-significant
|
Wang Y, 2007 |
|
|
HHRR P-value=0.177, X2=1.82; TDT P-value>0.05, X<......
HHRR P-value=0.177, X2=1.82; TDT P-value>0.05, X2=1.8
More...
|
not significantly associated with ADHD
not significantly associated with ADHD
|
Non-significant
|
Langley K, 2009 |
|
|
Case-control analysis: P-value=0.61 for baseline ADHD; P-val......
Case-control analysis: P-value=0.61 for baseline ADHD; P-value=0.54 for persistent ADHD.
More...
|
not associated with persistent ADHD or baseline ADHD
not associated with persistent ADHD or baseline ADHD
|
Non-significant
|
Wohl M, 2008 |
|
|
TDT P-value=1.00, Mc Nemar X2=0.00 (df=1)
TDT P-value=1.00, Mc Nemar X2=0.00 (df=1)
|
showed a perfect lack of transmission bias
showed a perfect lack of transmission bias
|
Non-significant
|
Carrasco X, 2006 |
|
|
Fisher's exact test P-value=0.2673
Fisher's exact test P-value=0.2673
|
not significantly different from unaffected siblings
not significantly different from unaffected siblings
|
Non-significant
|
Kim JW, 2006 |
|
|
7R: chi-square P-value>0.05; 9R: P-value=0.03, OR=4.43, X
7R: chi-square P-value>0.05; 9R: P-value=0.03, OR=4.43, X2=11.55 in the ADHD probands; P-value=0.03, X2=12.70 in parents of probands; 10R/11R: chi-square P-value>0.05
More...
|
showed no significant association between 7R, 10R and 11R an......
showed no significant association between 7R, 10R and 11R and ADHD; suggested the possibility of an association between 9R and ADHD
More...
|
Significant
|
Kim YS, 2005 |
|
10R |
allelic TDT P-value=0.81; X2=2 for 6R; X2
allelic TDT P-value=0.81; X2=2 for 6R; X2=0.14 for 7R; X2=0 for 9R; X2=0.03 for 10R; X2=0 for 11R
More...
|
did not show preferential transmission of any allele
did not show preferential transmission of any allele
|
Non-significant
|
Todd RD, 2005 |
|
440bp allele |
TRANSMIT P-value=0.09 for 440bp allele; TRANSMIT P-value=0.1......
TRANSMIT P-value=0.09 for 440bp allele; TRANSMIT P-value=0.1 for 480bp allele
More...
|
there was a trend for significant under-transmission of the ......
there was a trend for significant under-transmission of the 440 and 480 base pair allele for the DSM-IV combined ADHD subtype in the total sample
More...
|
Non-significant
|
Langley K, 2005 |
|
10R |
TDT P-value=0.61, Z-statistic=0.27 for 9R; TDT P-value=0.55,......
TDT P-value=0.61, Z-statistic=0.27 for 9R; TDT P-value=0.55, Z-statistic=0.39 for 10R in the family-based analysis; P-value=0.912, X2(1df)=0.12, OR=1.0 in the case-control analysis
More...
|
no significant evidence for association was detected in the ......
no significant evidence for association was detected in the family-based and case-control analysis
More...
|
Non-significant
|
Feng Y, 2005(a) |
|
|
allelic TDT P-value (2-sided)=1, X2=0 of 10R; TDT......
allelic TDT P-value (2-sided)=1, X2=0 of 10R; TDT P-value (2-sided)=0.934, X2=0.007 of 9R
More...
|
no significant association
no significant association
|
Non-significant
|
Ouakil DP, 2005 |
|
10R |
P-value=0.21, X2(1df)=1.6; heterogeneity P-value=......
P-value=0.21, X2(1df)=1.6; heterogeneity P-value=0.0009, X2(12df)=33.13
More...
|
the meta-analysis showed no significant association between ......
the meta-analysis showed no significant association between ADHD and the SLC6A3 gene, but an important between-samples heterogeneity
More...
|
Non-significant
|
Simsek M, 2005 |
|
10R |
observed genotype frequencies, P-value>0.05; risk allele (10......
observed genotype frequencies, P-value>0.05; risk allele (10R) distribution, P-value=0.06, X2(df=1)=3.65
More...
|
lack of a significant difference between cases and controls
lack of a significant difference between cases and controls
|
Non-significant
|
Qian Q, 2007 |
|
|
Chi-square test: long- and short-repeat genotype analysis: P......
Chi-square test: long- and short-repeat genotype analysis: P-value=0.032 for ADHD, P-value=0.014 for ADHD-C, P-value=0.007 for ADHD refined phenotype, P-value=0.029 for pure ADHD; long- and short-repeat allele analysis: P-value=0.037 for ADHD, P-value=0.017 for ADHD-C, P-value=0.009 for ADHD refined phenotype, P-value=0.032 for pure ADHD
More...
|
The long-repeat genotypes and alleles were seen more frequen......
The long-repeat genotypes and alleles were seen more frequently in ADHD probands than in controls. For ADHD subtypes, similar results were found.
More...
|
Significant
|
Genro JP, 2007 |
|
|
Allelic test P-value=0.78 in the total sample, P-value=0.78 ......
Allelic test P-value=0.78 in the total sample, P-value=0.78 in combined type sample; TDT analysis P-value=0.63 in the total sample, P-value=0.42 in combined type sample
More...
|
Either on the total sample or on the combined one, no allele......
Either on the total sample or on the combined one, no allele was significantly more transmitted than expected for the 3'-VNTR polymorphism in the families with ADHD children.
More...
|
Non-significant
|
Simsek M, 2006 |
|
|
P-value>0.05
P-value>0.05
|
indicated absence of any strong association
indicated absence of any strong association
|
Non-significant
|
Li D, 2006 |
440-, 480-, 520-bp allele |
|
allele 440-bp: overall P(Z) P-value=0.6418, heterogeneity P(......
allele 440-bp: overall P(Z) P-value=0.6418, heterogeneity P(Q) P-value=0.7829, publication bias P(T) P-value=0.309, overall OR=1.02; Heterogeneity test between design types, P(Q) P-value=0.4536, Heterogeneity test between sample ethnicities, P(Q) P-value=0.0749; allele 480-bp: overall P(Z) P-value=0.1955, heterogeneity P(Q) P-value=1E-6, publication bias P(T) P-value=0.065, overall OR=1.04; Heterogeneity test between design types, P(Q) P-value=0.1759, Heterogeneity test between sample ethnicities, P(Q) P-value=0.0792; allele 520-bp: overall P(Z) P-value=0.05, heterogeneity P(Q) P-value=0.9236, publication bias P(T) P-value=0.729, overall OR=1.48; Heterogeneity test between design types, P(Q) P-value=0.2926, Heterogeneity test between sample ethnicities, P(Q) P-value=0.5349.
More...
|
allele 440-bp showed no significant association; allele 480-......
allele 440-bp showed no significant association; allele 480-bp showed no significant association; allele 520-bp showed weak significant association.
More...
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Non-significant
|
Cheuk DK, 2006(b) |
6, 9, 10, 11 repeat |
10-repeat |
TDT test for 10-repeat allele: P-value=0.99 for all ADHD sam......
TDT test for 10-repeat allele: P-value=0.99 for all ADHD sample, P-value=0.92 for combined subtype; Case-Control test for 10-repeat allele: OR=0.89, 95%CI = 0.35-2.28, P-value=0.81.
More...
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showed no significant association
showed no significant association
|
Non-significant
|
Lim MH, 2006 |
|
|
7R: TDT P-value=0.036, X2=4.5; 9R: TDT P-value=0.......
7R: TDT P-value=0.036, X2=4.5; 9R: TDT P-value=0.036, X2=4.5; 10R: TDT P-value=0.0011, X2=10.71, OR=7.88; 11R: TDT P-value=NS, X2=1.8
More...
|
preferentially transmitted to ADHD children for 7R, 9R and 1......
preferentially transmitted to ADHD children for 7R, 9R and 10R; 11R was not preferentially transmitted to ADHD children
More...
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Significant
|
Hawi Z, 2005 |
|
|
TDT P-value=0.048, X2=4.4, OR=1.8 for paternel tr......
TDT P-value=0.048, X2=4.4, OR=1.8 for paternel transmission; TDT P-value=0.41, X2=0.9, OR=0.8 for maternal transmission
More...
|
nominal significant overtransmission of paternal alleles was......
nominal significant overtransmission of paternal alleles was seen, no significant association was observed for maternal transmission
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|
Significant
|
Brookes KJ, 2006(b) |
|
|
TDT P-value=0.003 in English group; TDT P-value=0.001 in Tai......
TDT P-value=0.003 in English group; TDT P-value=0.001 in Taiwanese group
More...
|
provide global evidence of association and linkage
provide global evidence of association and linkage
|
Significant
|
Das M, 2011 |
|
|
ETDT P-value=1, X2(1df)=0, RR=1; allelic frequenc......
ETDT P-value=1, X2(1df)=0, RR=1; allelic frequencies COCAPHASE P-value=0.99, X2=0.0001 for 11R; ETDT P-value=0.08, X2(1df)=3.1, RR=0.84; allelic frequencies COCAPHASE P-value=0.34, X2=0.92 for 10R; ETDT P-value=0.14, X2(1df)=2.19, RR=1.35; allelic frequencies COCAPHASE P-value=0.61, X2=0.26 for 9R; ETDT P-value=1, X2(1df)=0, RR=0.85; allelic frequencies COCAPHASE P-value=0.83, X2=0.04 for 8R; ETDT P-value=0.25, X2(1df)=1.33, RR=2.25; allelic frequencies COCAPHASE P-value=0.02, X2=5.6 for 7R
More...
|
the data was statistically not significant in either case-co......
the data was statistically not significant in either case-control or family-based analysis for 8R, 9R, 10R and 11R; no significant contribution was noticed by family-based analysis; case-control analysis revealed statistically significant difference for the 7R
More...
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Significant
|
Brown, A. B., 2011 |
9R |
|
P-value=0.004, X2=8.34
P-value=0.004, X2=8.34
|
There was a statistically significant difference, indicating......
There was a statistically significant difference, indicating that the 9R allele was more frequent in the ADHD sample.
More...
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Significant
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El-Tarras, A. E., 2012 |
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allelic P-value<0.01, OR=2.5, CI=1.4-4.6 for 7R; P-value<0.0......
allelic P-value<0.01, OR=2.5, CI=1.4-4.6 for 7R; P-value<0.01, OR=0.4, CI=0.2-0.6 for 9R; P-value<0.01, OR=0.4, CI=0.3-0.5 for 10R; P-value<0.01, OR=3.3, CI=2.3-4.8 for 11R; genotypic P-value<0.01, OR=0.3, CI=0.1-0.6 for 10/10; P-value<0.01, OR=0.3, CI=0.2-0.5 for 10/9; P-value<0.01, OR=4, CI=2.1-7.9 for 11/11; P-value=0.01, OR=3, CI=1.4-7 for 11/7; P-value=0.4, OR=1.4, CI=0.7-2.8 for 11/10; P-value=0.08, OR=2.1, CI=0.9-5.1 for 10/7
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Among DAT1 allele and genotypes there were statistically str......
Among DAT1 allele and genotypes there were statistically strong association between 7 and 11 repeats and ADHD (OR: 2.5 and 3.3) respectively. While, repeats 9 and 10 seems to have protective effects. 11/11 and 11/7 genotypes, revealed strong significant associated with ADHD (OR = 4 and 3) respectively.
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Significant
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Spencer, T. J., 2012 |
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9R |
P-value=NS, X2=0.53
P-value=NS, X2=0.53
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the gene frequencies of each of the gene polymorphisms asses......
the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups.
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Non-significant
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Aparecida da Silva M, 2011 |
4, 7-11 repeat |
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allelic chi-square test P-value=0.75 (5df); genotypic chi-sq......
allelic chi-square test P-value=0.75 (5df); genotypic chi-square test P-value=0.61 (9df)
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There is no association between adult ADHD and VNTR 3'UTR po......
There is no association between adult ADHD and VNTR 3'UTR polymorphism
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Non-significant
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Shang CY, 2011 |
9/10 repeats |
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10-repeat allele FBAT P-value=0.059, Z=1.886 for total sampl......
10-repeat allele FBAT P-value=0.059, Z=1.886 for total sample; 10-repeat allele FBAT P-value=0.423, Z=0.801 for combined subtype; 10-repeat allele FBAT P-value=0.061, Z=1.877 for inattentive subtype
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displayed trends for association with ADHD; displayed a tren......
displayed trends for association with ADHD; displayed a trend for association in inattentive subtype
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Non-significant
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Ilott NE, 2010 |
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QTDT AT P-value=0.03, X2=7, df=2, QTDT AW P-value......
QTDT AT P-value=0.03, X2=7, df=2, QTDT AW P-value=0.08, X2=5.09, df=2 at age 2; QTDT AT P-value=0.004, X2=11.15, df=2, QTDT AW P-value=0.002, X2=12.17, df=2 at age 3
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modest, nominally significant associations in the AT test at......
modest, nominally significant associations in the AT test at age 2, and in the AT and AW tests at age 3, and still significant after bonferroni correction in the AW test at age 3
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Significant
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Bidwell LC, 2011 |
9/10 repeat |
10-repeat |
FBAT-GEE: total ADHD, P-value=0.03 (negative association) fo......
FBAT-GEE: total ADHD, P-value=0.03 (negative association) for 9-repeat allele, P-value=0.02 (positive association) for 10-repeat allele; Inattentive, P-value=0.009 (negative association) for 9-repeat allele, P-value=0.005 (positive association) for 10-repeat allele; Hyperactive/impulsive, P-value=0.57 for 9-repeat allele, P-value=0.47 for 10-repeat allele
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the 10-repeat allele significantly associated with common AD......
the 10-repeat allele significantly associated with common ADHD phenotype and the inattentive symptoms.
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Significant
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