ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name SLC6A3_3'-UTR_VNTR
Type VNTR
Location 3' UTR
Length of Repeat Unit 40bp
Related Gene SLC6A3
No. of Study 56 (significant: 22; non-significant 34; trend: 0)

Variant related studies (count: 56)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Gill M, 1997 480 bp HRR P=0.014 (df=1) for allele 480 bp HRR P=0.014 (df=1) for allele 480 bp HRR analysis revealed a significant association between ADHD...... HRR analysis revealed a significant association between ADHD and the 480-bp DAT1 allele. The 480-bp allele was preferentially transmitted to ADHD probands. More... Significant
Li D, 2006 440-, 480-, 520-bp allele allele 440-bp: overall P(Z) P-value=0.6418, heterogeneity P(...... allele 440-bp: overall P(Z) P-value=0.6418, heterogeneity P(Q) P-value=0.7829, publication bias P(T) P-value=0.309, overall OR=1.02; Heterogeneity test between design types, P(Q) P-value=0.4536, Heterogeneity test between sample ethnicities, P(Q) P-value=0.0749; allele 480-bp: overall P(Z) P-value=0.1955, heterogeneity P(Q) P-value=1E-6, publication bias P(T) P-value=0.065, overall OR=1.04; Heterogeneity test between design types, P(Q) P-value=0.1759, Heterogeneity test between sample ethnicities, P(Q) P-value=0.0792; allele 520-bp: overall P(Z) P-value=0.05, heterogeneity P(Q) P-value=0.9236, publication bias P(T) P-value=0.729, overall OR=1.48; Heterogeneity test between design types, P(Q) P-value=0.2926, Heterogeneity test between sample ethnicities, P(Q) P-value=0.5349. More... allele 440-bp showed no significant association; allele 480-...... allele 440-bp showed no significant association; allele 480-bp showed no significant association; allele 520-bp showed weak significant association. More... Non-significant
Smith KM, 2003 10R Genotype groupings chi-square P-value=0.840, Allele grouping...... Genotype groupings chi-square P-value=0.840, Allele groupings chi-square P-value=0.740 More... no significant differences were observed no significant differences were observed Non-significant
Waldman ID, 1998 3-11 repeats 10R Between-family association t-test: one-tailed P=0.032 for HI...... Between-family association t-test: one-tailed P=0.032 for HI symptoms, one-tailed P=0.137 for IA symptoms; Within-family analyses using genetically discordant siblings: Wilcoxon signed ranks test one-tailed P=0.008 for HI symptoms, one-tailed P=0.011 for IA symptoms; Within-family TDT test by ADHD diagnosis,severity level, and genetic model: P=0.0349 for any diagnosis at medium level of symptom severity, P=0.0106 for any diagnosis at high level of severity, P=0.0374 for combined tyep at low level of severity, P=0.0163 for combined tyep at medium level of severity, P=0.0325 for combined tyep at high level of severity, P=0.0387 for combined tyep at medium level of severity under recessive model. More... Within-family analyses of LD confirmed the 480-bp allele (10...... Within-family analyses of LD confirmed the 480-bp allele (10-repeat) as the high-risk allele. In between-family association analyses, levels of HI symptoms but not IA symptoms were related to the number of DAT1 high-risk alleles. Siblings discordant for the number of DAT1 high-risk alleles differed markedly in their levels of both HI and IA symptoms. Within-family analyses of LD, using the TDT, suggested association and linkage of ADHD with DAT1 and that this relation was especially strong with the combined but not the inattentive subtype. The relation of DAT1 to ADHD increased monotonically, from low to medium to high levels of symptom severity. More... Significant
Chen CK, 2003 10R TDT P-value=0.001, X2(1.df)=10.8, OR=2.9 TDT P-value=0.001, X2(1.df)=10.8, OR=2.9 found evidence of increased transmission of the 10-repeat al...... found evidence of increased transmission of the 10-repeat allele More... Significant
Brown, A. B., 2011 9R P-value=0.004, X2=8.34 P-value=0.004, X2=8.34 There was a statistically significant difference, indicating...... There was a statistically significant difference, indicating that the 9R allele was more frequent in the ADHD sample. More... Significant
Kustanovich V, 2004 GRR=1.39, TDT P-value=0.484 GRR=1.39, TDT P-value=0.484 No evidence for an association was found No evidence for an association was found Non-significant
Brookes KJ, 2006(b) TDT P-value=0.003 in English group; TDT P-value=0.001 in Tai...... TDT P-value=0.003 in English group; TDT P-value=0.001 in Taiwanese group More... provide global evidence of association and linkage provide global evidence of association and linkage Significant
Lim MH, 2006 7R: TDT P-value=0.036, X2=4.5; 9R: TDT P-value=0....... 7R: TDT P-value=0.036, X2=4.5; 9R: TDT P-value=0.036, X2=4.5; 10R: TDT P-value=0.0011, X2=10.71, OR=7.88; 11R: TDT P-value=NS, X2=1.8 More... preferentially transmitted to ADHD children for 7R, 9R and 1...... preferentially transmitted to ADHD children for 7R, 9R and 10R; 11R was not preferentially transmitted to ADHD children More... Significant
Simsek M, 2006 P-value>0.05 P-value>0.05 indicated absence of any strong association indicated absence of any strong association Non-significant
Cheuk DK, 2006(b) 6, 9, 10, 11 repeat 10-repeat TDT test for 10-repeat allele: P-value=0.99 for all ADHD sam...... TDT test for 10-repeat allele: P-value=0.99 for all ADHD sample, P-value=0.92 for combined subtype; Case-Control test for 10-repeat allele: OR=0.89, 95%CI = 0.35-2.28, P-value=0.81. More... showed no significant association showed no significant association Non-significant
Bidwell LC, 2011 9/10 repeat 10-repeat FBAT-GEE: total ADHD, P-value=0.03 (negative association) fo...... FBAT-GEE: total ADHD, P-value=0.03 (negative association) for 9-repeat allele, P-value=0.02 (positive association) for 10-repeat allele; Inattentive, P-value=0.009 (negative association) for 9-repeat allele, P-value=0.005 (positive association) for 10-repeat allele; Hyperactive/impulsive, P-value=0.57 for 9-repeat allele, P-value=0.47 for 10-repeat allele More... the 10-repeat allele significantly associated with common AD...... the 10-repeat allele significantly associated with common ADHD phenotype and the inattentive symptoms. More... Significant
Das M, 2011 ETDT P-value=1, X2(1df)=0, RR=1; allelic frequenc...... ETDT P-value=1, X2(1df)=0, RR=1; allelic frequencies COCAPHASE P-value=0.99, X2=0.0001 for 11R; ETDT P-value=0.08, X2(1df)=3.1, RR=0.84; allelic frequencies COCAPHASE P-value=0.34, X2=0.92 for 10R; ETDT P-value=0.14, X2(1df)=2.19, RR=1.35; allelic frequencies COCAPHASE P-value=0.61, X2=0.26 for 9R; ETDT P-value=1, X2(1df)=0, RR=0.85; allelic frequencies COCAPHASE P-value=0.83, X2=0.04 for 8R; ETDT P-value=0.25, X2(1df)=1.33, RR=2.25; allelic frequencies COCAPHASE P-value=0.02, X2=5.6 for 7R More... the data was statistically not significant in either case-co...... the data was statistically not significant in either case-control or family-based analysis for 8R, 9R, 10R and 11R; no significant contribution was noticed by family-based analysis; case-control analysis revealed statistically significant difference for the 7R More... Significant
Holmes J, 2000 5, 8-11 repeats 10-repeat Case-control analysis: overall P-value=0.82; TDT analysis: o...... Case-control analysis: overall P-value=0.82; TDT analysis: overall P-value=0.75 More... no evidence of association with SLC6A3 using either TDT or c...... no evidence of association with SLC6A3 using either TDT or case control analysis More... Non-significant
Asherson P, 2007 TDT P-value=0.0186 for 3'UTR VNTR; 10R: TDT P-value=0.010, O...... TDT P-value=0.0186 for 3'UTR VNTR; 10R: TDT P-value=0.010, OR=0.21; 9R: TDT P-value=0.005, OR=0.81 More... global evidence for association with the 3'UTR VNTR; 9R and ...... global evidence for association with the 3'UTR VNTR; 9R and 10R were associated with risk for ADHD More... Significant
Bruggemann D, 2007 no P-value no P-value no association was found when testing single markers no association was found when testing single markers Non-significant
Barr CL, 2001(a) 200-520bp allelic TDT two-sided P-value=0.110, one-sided P-value=0.055...... allelic TDT two-sided P-value=0.110, one-sided P-value=0.055, X2=2.56 for 480bp, allelic TDT two-sided P-value=0.123, one-sided P-value=0.064, X2=2.32 for 440bp More... the TDT was not significant for any allele of the polymorphi...... the TDT was not significant for any allele of the polymorphism, but there was a trend for the biased transmission of the 480bp allele of the VNTR to the ADHD probands More... Non-significant
Yang B, 2007 Meta-Analysis: TDT P-value=0.004, OR=1.17, 95%CI=1.05-1.30; ...... Meta-Analysis: TDT P-value=0.004, OR=1.17, 95%CI=1.05-1.30; HHRR P-value=0.07, OR=1.50, 95%CI=0.97-2.33; Case-Control P-value=0.54, OR=0.95, 95%CI=0.80-1.12 More... There were statistically significant evidences for heterogen...... There were statistically significant evidences for heterogeneity of the odds ratio in TDT and HHRR studies, but not in case-control studies. More... Significant
Das M, 2007 9-, 10-repeat 9-repeat allele: HHRR P-value=0.009, OR=2.3; TDT P-value=0.0...... 9-repeat allele: HHRR P-value=0.009, OR=2.3; TDT P-value=0.002, RR=3.11; FBAT P-value=0.019. 10-repeat allele: FBAT P-value=0.032. More... The observed transmission of the 9R allele deviated signific...... The observed transmission of the 9R allele deviated significantly from that of the expected transmission. More... Significant
Banoei MM, 2008 chi-square P-value=0.9, X2=0.081 chi-square P-value=0.9, X2=0.081 no association between 10-allele and ADHD no association between 10-allele and ADHD Non-significant
Qian Q, 2007 Chi-square test: long- and short-repeat genotype analysis: P...... Chi-square test: long- and short-repeat genotype analysis: P-value=0.032 for ADHD, P-value=0.014 for ADHD-C, P-value=0.007 for ADHD refined phenotype, P-value=0.029 for pure ADHD; long- and short-repeat allele analysis: P-value=0.037 for ADHD, P-value=0.017 for ADHD-C, P-value=0.009 for ADHD refined phenotype, P-value=0.032 for pure ADHD More... The long-repeat genotypes and alleles were seen more frequen...... The long-repeat genotypes and alleles were seen more frequently in ADHD probands than in controls. For ADHD subtypes, similar results were found. More... Significant
Martinez-Levy, G. A.,2013 HWE:F =-0.04; P-value=0.52 HWE:F =-0.04; P-value=0.52 No significant association was found for SLC6A_3`-UTR_VNTR No significant association was found for SLC6A_3`-UTR_VNTR Non-significant
Genro JP, 2007 Allelic test P-value=0.78 in the total sample, P-value=0.78 ...... Allelic test P-value=0.78 in the total sample, P-value=0.78 in combined type sample; TDT analysis P-value=0.63 in the total sample, P-value=0.42 in combined type sample More... Either on the total sample or on the combined one, no allele...... Either on the total sample or on the combined one, no allele was significantly more transmitted than expected for the 3'-VNTR polymorphism in the families with ADHD children. More... Non-significant
Qian Q, 2004 short(6-7R)/long(9-12R) case-control genotype X2 test: P-value=0.032 (OR=...... case-control genotype X2 test: P-value=0.032 (OR=2.068, 95%CI=1.050-4.070) for ADHD, P-value=0.014 (OR=2.529, 95%CI=1.178-5.431) for ADHD-C, P-value=0.029 (OR=2.488, 95% CI=1.074-5.764) for pure-ADHD; case-control allele X2 test: P-value=0.037 (OR=2.006, 96%CI=1.032-3.901) for ADHD, P-value=0.017 (OR=2.423, 95%CI=1.148-5.112) for ADHD-C, P-value=0.032 (OR=2.386, 95%CI=1.052-5.414) for pure-ADHD; HHRR P-value=0.411; ETDT P-value>0.05 More... long-repeat genotypes and alleles were seen more frequently ...... long-repeat genotypes and alleles were seen more frequently in ADHD probands than in controls; no overall evidence of association between SLC6A31 and ADHD according to HHRR analysis; no preferential transmission of any allele were found by ETDT test. More... Significant
Curran S, 2001 480bp allele TDT P-value=0.013, X2=6.119, OR=1.95 in the UK sa...... TDT P-value=0.013, X2=6.119, OR=1.95 in the UK sample; TDT P-value=0.335, X2=0.931, OR=0.81 in the Turkish sample; TDT P-value=0.063, X2=3.47, OR=1.16 in the combined analysis More... when considered alone, data from the UK sample but not the T...... when considered alone, data from the UK sample but not the Turkish sample supported association and linkage between the SLC6A3 locus and ADHD, and in the combined analysis, they find only a marginal change in overall significance More... Significant
El-Tarras, A. E., 2012 allelic P-value<0.01, OR=2.5, CI=1.4-4.6 for 7R; P-value<0.0...... allelic P-value<0.01, OR=2.5, CI=1.4-4.6 for 7R; P-value<0.01, OR=0.4, CI=0.2-0.6 for 9R; P-value<0.01, OR=0.4, CI=0.3-0.5 for 10R; P-value<0.01, OR=3.3, CI=2.3-4.8 for 11R; genotypic P-value<0.01, OR=0.3, CI=0.1-0.6 for 10/10; P-value<0.01, OR=0.3, CI=0.2-0.5 for 10/9; P-value<0.01, OR=4, CI=2.1-7.9 for 11/11; P-value=0.01, OR=3, CI=1.4-7 for 11/7; P-value=0.4, OR=1.4, CI=0.7-2.8 for 11/10; P-value=0.08, OR=2.1, CI=0.9-5.1 for 10/7 More... Among DAT1 allele and genotypes there were statistically str...... Among DAT1 allele and genotypes there were statistically strong association between 7 and 11 repeats and ADHD (OR: 2.5 and 3.3) respectively. While, repeats 9 and 10 seems to have protective effects. 11/11 and 11/7 genotypes, revealed strong significant associated with ADHD (OR = 4 and 3) respectively. More... Significant
Spencer, T. J., 2012 9R P-value=NS, X2=0.53 P-value=NS, X2=0.53 the gene frequencies of each of the gene polymorphisms asses...... the gene frequencies of each of the gene polymorphisms assessed did not differ between the ADHD and control groups. More... Non-significant
Roman T, 2001 10R allelic HRR P-value=0.88, X2=0.02 in the total sa...... allelic HRR P-value=0.88, X2=0.02 in the total sample, allelic HRR P-value=0.87, X2=0.02 in the combined type for 10R; allele frequencies chi-square between probands and controls =1.90, P-value=0.86, chi-square between parents and controls=6.52, P-value=0.39; P-value=0.41, X2=0.68 for other allele More... no preferential transmission for either the 10-repeat allele...... no preferential transmission for either the 10-repeat allele or other alleles was observed More... Non-significant
Franke B, 2008 Pearson chi-square P-value=0.085, OR=1 for 10/10 genotype fr...... Pearson chi-square P-value=0.085, OR=1 for 10/10 genotype frequency, OR=1.27 for 10/9 genotype frequency, OR=1.98 for 9/9 genotype frequency More... genotype analysis did not show significant differences betwe...... genotype analysis did not show significant differences between cases and controls More... Non-significant
Genro JP, 2008 9/10 repeats 9 repeat P-value=0.867 for total sample, P-value=0.458 for c...... 9 repeat P-value=0.867 for total sample, P-value=0.458 for combined sample; 10 repeat P-value=0.873 for total sample; P-value=0.365 for combined sample More... no allele was significantly more transmitted than expected no allele was significantly more transmitted than expected Non-significant
Wang Y, 2007 HHRR P-value=0.177, X2=1.82; TDT P-value>0.05, X<...... HHRR P-value=0.177, X2=1.82; TDT P-value>0.05, X2=1.8 More... not significantly associated with ADHD not significantly associated with ADHD Non-significant
Niederhofer H, 2008 6R HRR P-value=0.00, OR=1.0, X2=0.00; allelic TDT X<...... HRR P-value=0.00, OR=1.0, X2=0.00; allelic TDT X2=0.00, OR=1.0 in 36 trios. HRR OR=0.91, X2=0.04; allelic X2=0.17, OR=0.88 in 36 trios and 13 duos More... none of the alleles was significantly associated with ADHD n...... none of the alleles was significantly associated with ADHD neither by HRR nor TDT; a nonsignificant result was obtained by both HRR and TDT for the risk allele (6R) More... Non-significant
Bakker SC, 2005 10R allelic TDT P-value=0.73 allelic TDT P-value=0.73 no signs of a distorted transmissions of any of the single p...... no signs of a distorted transmissions of any of the single polymorphisms, or of single alleles More... Non-significant
Todd RD, 2001(a) ETDT P-value=1.00, X2(3df)=0.06 in DSM-IV inatten...... ETDT P-value=1.00, X2(3df)=0.06 in DSM-IV inattentive, ETDT P-value=0.23, X2(2df)=3.0 in DSM-IV combined, ETDT P-value=0.76, X2(1df)=0.09 in DSM-IV hyperactive, ETDT P-value=0.71, X2(3df)=1.4 in DSM-IV any ADHD; allele-wise P-value=0.28, corrected P-value=0.48, X2=1.18 for 10 repeat, allele-wise P-value=0.31, corrected P-value=0.52, X2=1.034 for 9 repeat in DSM-IV any ADHD; allele-wise P-value=0.16, corrected P-value=0.29, X2=1.976 for 10 repeat, allele-wise P-value=0.21, corrected P-value=0.37, X2=1.60 for 9 repeat in DSM-IV combined; allele-wise P-value=0.81, corrected P-value=0.97, X2=0.056 for 10 repeat, allele-wise P-value=0.81, corrected P-value=0.96, X2=0.059 for 9 repeat in DSM-IV inattentive; allele-wise P-value=0.76, corrected P-value=0.94, X2=0.091 for 10 repeat, allele-wise P-value=0.76, corrected P-value=0.94, X2=0.091 for 9 repeat in DSM-IV hyperactive/impulsive More... there was no significant transmission distortion for the SLC...... there was no significant transmission distortion for the SLC6A3 3' VNTR for any definition of ADHD and there was no significant allele-wise evidence for transmission distortion for any ADHD subtype for both the 10-repeat and 9-repeat alleles More... Non-significant
Simsek M, 2005 10R observed genotype frequencies, P-value>0.05; risk allele (10...... observed genotype frequencies, P-value>0.05; risk allele (10R) distribution, P-value=0.06, X2(df=1)=3.65 More... lack of a significant difference between cases and controls lack of a significant difference between cases and controls Non-significant
Ouellet-Morin I, 2008 9/10 allele QTDT P-value>0.05 in AP, AT, AO models at 6 and 7 years old QTDT P-value>0.05 in AP, AT, AO models at 6 and 7 years old no significant association no significant association Non-significant
Langley K, 2005 10R TDT P-value=0.61, Z-statistic=0.27 for 9R; TDT P-value=0.55,...... TDT P-value=0.61, Z-statistic=0.27 for 9R; TDT P-value=0.55, Z-statistic=0.39 for 10R in the family-based analysis; P-value=0.912, X2(1df)=0.12, OR=1.0 in the case-control analysis More... no significant evidence for association was detected in the ...... no significant evidence for association was detected in the family-based and case-control analysis More... Non-significant
Johansson S, 2008 Overall P-value=0.48; allelic P-value=0.59, OR=0.94 Overall P-value=0.48; allelic P-value=0.59, OR=0.94 showed no association showed no association Non-significant
Ouakil DP, 2005 10R P-value=0.21, X2(1df)=1.6; heterogeneity P-value=...... P-value=0.21, X2(1df)=1.6; heterogeneity P-value=0.0009, X2(12df)=33.13 More... the meta-analysis showed no significant association between ...... the meta-analysis showed no significant association between ADHD and the SLC6A3 gene, but an important between-samples heterogeneity More... Non-significant
Nyman ES, 2007 No available information. No available information. No evidence of association was seen. No evidence of association was seen. Non-significant
Langley K, 2009 Case-control analysis: P-value=0.61 for baseline ADHD; P-val...... Case-control analysis: P-value=0.61 for baseline ADHD; P-value=0.54 for persistent ADHD. More... not associated with persistent ADHD or baseline ADHD not associated with persistent ADHD or baseline ADHD Non-significant
Wohl M, 2008 TDT P-value=1.00, Mc Nemar X2=0.00 (df=1) TDT P-value=1.00, Mc Nemar X2=0.00 (df=1) showed a perfect lack of transmission bias showed a perfect lack of transmission bias Non-significant
Kim YS, 2005 10R allelic TDT P-value=0.81; X2=2 for 6R; X2 allelic TDT P-value=0.81; X2=2 for 6R; X2=0.14 for 7R; X2=0 for 9R; X2=0.03 for 10R; X2=0 for 11R More... did not show preferential transmission of any allele did not show preferential transmission of any allele Non-significant
Kirley A, 2002 480bp HHRR: P-value=0.0062 (RR=1.4, OR=1.88); TDT: P-value=0.042 (...... HHRR: P-value=0.0062 (RR=1.4, OR=1.88); TDT: P-value=0.042 (OR=1.63); TDT by presence of family history: P-value=0.494 (OR[95%CI]=1.87[0.47-7.35]); TDT of Paternal and Maternal transmissions: P-value=0.403 (OR[95%CI]=1.56[0.55-4.44]) More... Significant preferential transmission Significant preferential transmission Significant
Shang CY, 2011 9/10 repeats 10-repeat allele FBAT P-value=0.059, Z=1.886 for total sampl...... 10-repeat allele FBAT P-value=0.059, Z=1.886 for total sample; 10-repeat allele FBAT P-value=0.423, Z=0.801 for combined subtype; 10-repeat allele FBAT P-value=0.061, Z=1.877 for inattentive subtype More... displayed trends for association with ADHD; displayed a tren...... displayed trends for association with ADHD; displayed a trend for association in inattentive subtype More... Non-significant
Feng Y, 2005(a) allelic TDT P-value (2-sided)=1, X2=0 of 10R; TDT...... allelic TDT P-value (2-sided)=1, X2=0 of 10R; TDT P-value (2-sided)=0.934, X2=0.007 of 9R More... no significant association no significant association Non-significant
Ilott NE, 2010 QTDT AT P-value=0.03, X2=7, df=2, QTDT AW P-value...... QTDT AT P-value=0.03, X2=7, df=2, QTDT AW P-value=0.08, X2=5.09, df=2 at age 2; QTDT AT P-value=0.004, X2=11.15, df=2, QTDT AW P-value=0.002, X2=12.17, df=2 at age 3 More... modest, nominally significant associations in the AT test at...... modest, nominally significant associations in the AT test at age 2, and in the AT and AW tests at age 3, and still significant after bonferroni correction in the AW test at age 3 More... Significant
Maher BS, 2002 P-value=0.06, pooled OR=1.27; test of homogeneity P-value=0....... P-value=0.06, pooled OR=1.27; test of homogeneity P-value=0.37, Q=10.85, df=10 More... no positive association was demostrated with ADHD in the met...... no positive association was demostrated with ADHD in the meta-analysis More... Non-significant
Hawi Z, 2005 TDT P-value=0.048, X2=4.4, OR=1.8 for paternel tr...... TDT P-value=0.048, X2=4.4, OR=1.8 for paternel transmission; TDT P-value=0.41, X2=0.9, OR=0.8 for maternal transmission More... nominal significant overtransmission of paternal alleles was...... nominal significant overtransmission of paternal alleles was seen, no significant association was observed for maternal transmission More... Significant
Carrasco X, 2006 Fisher's exact test P-value=0.2673 Fisher's exact test P-value=0.2673 not significantly different from unaffected siblings not significantly different from unaffected siblings Non-significant
Kim JW, 2006 7R: chi-square P-value>0.05; 9R: P-value=0.03, OR=4.43, X 7R: chi-square P-value>0.05; 9R: P-value=0.03, OR=4.43, X2=11.55 in the ADHD probands; P-value=0.03, X2=12.70 in parents of probands; 10R/11R: chi-square P-value>0.05 More... showed no significant association between 7R, 10R and 11R an...... showed no significant association between 7R, 10R and 11R and ADHD; suggested the possibility of an association between 9R and ADHD More... Significant
Gizer IR, 2009 Meta-analysis model: Random: OR=1.12, 95% CI=1.00-1.27, P-va...... Meta-analysis model: Random: OR=1.12, 95% CI=1.00-1.27, P-value=0.028; Q-statistic: P-value=0.000001, I2=65 More... significant but modest association significant but modest association Significant
Hawi Z, 2003 Global X2=0.02; HHRR P-value=0.56, X2=...... Global X2=0.02; HHRR P-value=0.56, X2=0.34, RR=0.66 for allele1; HHRR P-value=0.0062, X2=7.5, RR=1.4 for allele2 More... significant association between allele 2 (480 bp) of the SLC...... significant association between allele 2 (480 bp) of the SLC6A3 VNTR polymorphism and ADHD was reported More... Significant
Todd RD, 2005 440bp allele TRANSMIT P-value=0.09 for 440bp allele; TRANSMIT P-value=0.1...... TRANSMIT P-value=0.09 for 440bp allele; TRANSMIT P-value=0.1 for 480bp allele More... there was a trend for significant under-transmission of the ...... there was a trend for significant under-transmission of the 440 and 480 base pair allele for the DSM-IV combined ADHD subtype in the total sample More... Non-significant
Aparecida da Silva M, 2011 4, 7-11 repeat allelic chi-square test P-value=0.75 (5df); genotypic chi-sq...... allelic chi-square test P-value=0.75 (5df); genotypic chi-square test P-value=0.61 (9df) More... There is no association between adult ADHD and VNTR 3'UTR po...... There is no association between adult ADHD and VNTR 3'UTR polymorphism More... Non-significant
Franke B, 2010 9/9 genotype P-value=0.005, OR=1.5, X2 (1df)=8.15...... 9/9 genotype P-value=0.005, OR=1.5, X2 (1df)=8.15, meta-analysis P-value=0.03, OR=1.34; 10/10 genotype meta-analysis P-value=0.29, OR=0.93 More... the 9/9 genotype of the 3'-UTR VNTR showed association with ...... the 9/9 genotype of the 3'-UTR VNTR showed association with the disorder in adults in the combined and meta-analysis More... Significant