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- Data Summary
GO Report
Basic Info
| ID | GO:0005085 |
|---|---|
| Name | guanyl-nucleotide exchange factor activity |
| Type | Molecular Function |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
PBA Result (with statistical significance of FDR<0.05)
GO related genes in ADHDgene (count: 17)
Literature-origin genes (count: 3)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
Evidence[PMID] |
|---|---|---|---|---|
| TRIO | triple functional domain (PTPRF interacting) | 5p14-p15.1 | 1(0/0/1) | TAS[8643598] |
| NET1 | neuroepithelial cell transforming 1 | 10p15 | 0 | TAS[8649828] |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 6q25 | 1(0/0/1) | TAS[10512681] |
Genes from other sources (count: 14)
| Approved Symbol | Approved Name | Source | Evidence[PMID] |
|---|---|---|---|
| HERC2 | hect domain and RLD 2 | Mapped by significant region | NAS[9949213] |
| SPATA13 | spermatogenesis associated 13 | Mapped by CNV | IDA[19934221]; IMP[17599059] |
| GAPVD1 | GTPase activating protein and VPS9 domains 1 | Mapped by significant region | IMP[16410077] |
| FGD3 | FYVE, RhoGEF and PH domain containing 3 | Mapped by significant region | |
| EIF2B1 | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa | Mapped by CNV | IDA[11323413] |
| RASGEF1C | RasGEF domain family, member 1C | Mapped by CNV | |
| ARHGEF17 | Rho guanine nucleotide exchange factor (GEF) 17 | Mapped by significant region | IDA[12071859] |
| RALGPS1 | Ral GEF with PH domain and SH3 binding motif 1 | Mapped by significant region | NAS[10747847] |
| RASGRP2 | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | Mapped by significant region | TAS[9789079] |
| DOCK8 | dedicator of cytokinesis 8 | Mapped by CNV | |
| PLCE1 | phospholipase C, epsilon 1 | Mapped by PBA pathway | TAS[11022047] |
| LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | Mapped by significant region | |
| RGL4 | ral guanine nucleotide dissociation stimulator-like 4 | Mapped by CNV | |
| ARHGEF4 | Rho guanine nucleotide exchange factor (GEF) 4 | Mapped by CNV; Mapped by significant region | IMP[17599059] |