ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SYN3
Approved Name	synapsin III
Location	22q12.3
Position	chr22:32908539-33454377, -
External Links	HGNC: 11496 Entrez Gene: 8224 Ensembl: ENSG00000185666 UCSC: uc003amx.2
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Makkar R, 2007	minimum TRANSMIT P-value=0.101 for the five-marker haplotype; the data did not support SYN3 as a major contributor to the genetic susceptibility of ADHD	Non-significant

Gene related SNPs (count: 64)

Literature-origin SNPs (count: 5)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs242089	Chr22:33213319(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1056484	Chr22:32908738(Fwd)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs3788459	Chr22:32966495(Fwd)	intron_variant	1(0/1/0)
rs133945	Chr22:33402843(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)
rs133946	Chr22:33403278(Fwd)	intron_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 59)

rs_ID	Location	Functional Annotation
rs738980	Chr22:32907362(Fwd)	downstream_gene_variant
rs4257479	Chr22:32908291(Fwd)	downstream_gene_variant
rs242088	Chr22:33219887(Fwd)	intron_variant; nc_transcript_variant
rs242085	Chr22:33221030(Fwd)	intron_variant; nc_transcript_variant
rs738992	Chr22:33210005(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs713996	Chr22:33177778(Fwd)	intron_variant; nc_transcript_variant; upstream_gene_variant
rs13057881	Chr22:33181818(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs9609632	Chr22:33183979(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs242078	Chr22:33228692(Fwd)	intron_variant; nc_transcript_variant
rs242071	Chr22:33237191(Fwd)	intron_variant; nc_transcript_variant
rs242076	Chr22:33229830(Fwd)	intron_variant; nc_transcript_variant
rs242072	Chr22:33235517(Fwd)	intron_variant; nc_transcript_variant
rs242077	Chr22:33229685(Fwd)	intron_variant; nc_transcript_variant
rs739143	Chr22:33421826(Fwd)	intron_variant
rs133941	Chr22:33398087(Fwd)	intron_variant
rs470011	Chr22:33418564(Fwd)	intron_variant
rs133962	Chr22:33418856(Fwd)	intron_variant
rs1894450	Chr22:32907721(Fwd)	downstream_gene_variant
rs130444	Chr22:32913733(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs2097312	Chr22:32912277(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs71699	Chr22:33401215(Fwd)	intron_variant
rs133966	Chr22:33419703(Fwd)	intron_variant
rs133943	Chr22:33401784(Fwd)	intron_variant
rs133942	Chr22:33401355(Fwd)	intron_variant
rs1012082	Chr22:33408799(Fwd)	intron_variant; upstream_gene_variant
rs133948	Chr22:33404546(Fwd)	intron_variant; upstream_gene_variant
rs470008	Chr22:33411446(Fwd)	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs470007	Chr22:33408943(Fwd)	intron_variant; upstream_gene_variant
rs133938	Chr22:33396435(Fwd)	intron_variant
rs133937	Chr22:33395851(Fwd)	intron_variant
rs133944	Chr22:33401968(Fwd)	intron_variant
rs470006	Chr22:33398069(Fwd)	intron_variant
rs5754377	Chr22:33410908(Fwd)	intron_variant; upstream_gene_variant
rs114509	Chr22:33408668(Fwd)	intron_variant; upstream_gene_variant
rs133965	Chr22:33419532(Fwd)	intron_variant
rs133959	Chr22:33416478(Fwd)	intron_variant
rs133949	Chr22:33405273(Fwd)	intron_variant; upstream_gene_variant
rs78506	Chr22:33414164(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs133926	Chr22:33392076(Fwd)	intron_variant
rs133931	Chr22:33394067(Fwd)	intron_variant
rs133934	Chr22:33395296(Fwd)	intron_variant
rs9621488	Chr22:32953435(Fwd)	intron_variant
rs9621489	Chr22:32953459(Fwd)	intron_variant
rs2710385	Chr22:32953258(Fwd)	intron_variant
rs5998545	Chr22:32968093(Fwd)	intron_variant
rs3788460	Chr22:32966546(Fwd)	intron_variant
rs3788456	Chr22:32966309(Fwd)	intron_variant
rs3788455	Chr22:32966267(Fwd)	intron_variant
rs1962222	Chr22:32971900(Fwd)	intron_variant
rs2858347	Chr22:32970662(Fwd)	intron_variant
rs2710355	Chr22:32970169(Fwd)	intron_variant
rs739008	Chr22:32963295(Fwd)	intron_variant
rs5998541	Chr22:32959473(Fwd)	intron_variant
rs4821073	Chr22:32958641(Fwd)	intron_variant
rs2710386	Chr22:32954443(Fwd)	intron_variant
rs4333019	Chr22:32966107(Fwd)	intron_variant
rs1016742	Chr22:32965049(Fwd)	intron_variant
rs1016741	Chr22:32964990(Fwd)	intron_variant
rs1016740	Chr22:32963983(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 6)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0008021	synaptic vesicle	Cellular Component	TAS[9539796]	13
GO:0030054	cell junction	Cellular Component		77
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0005524	ATP binding	Molecular Function		228
GO:0003824	catalytic activity	Molecular Function		15

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SYN3 (count: 0)

Genes shared at least 2 KEGG pathways with SYN3 (count: 0)

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Region: chr22:32908539..33454377 View in gBrowse