ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs133946 dbSNP Ensembl
Location	chr22:33403278(Fwd)
Variant Alleles	G/C
Ancestral Allele	G
Functional Annotation	intron_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000358763; ENST00000412575; ENST00000441821) upstream_gene_variant(ENST00000332840)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Makkar R, 2007	C/G		TDT P-value=0.283, X²=1.154 TDT P-value=0.283, X²=1.154	no significant biased transmission for any of the alleles of...... no significant biased transmission for any of the alleles of the polymorphism was observed using the TDT More...	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SYN3	synapsin III	22q12.3	2(1/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs133946 (count: 25) View in gBrowse (chr22:33392076..33421826 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 25)

rs_ID	Functional Annotation	r²[population]
rs470007	intron_variant; upstream_gene_variant	0.948[CHB]; 0.841[JPT]
rs470006	intron_variant	1.0[CEU]; 0.954[TSI]; 1.0[CHB]; 1.0[CHD]; 0.943[JPT]; 1.0[GIH]; 0.906[MEX]
rs133943	intron_variant	0.948[CHB]; 0.904[CHD]; 0.841[JPT]
rs133949	intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[TSI]; 1.0[ASW]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 1.0[GIH]; 0.846[LWK]; 1.0[MEX]; 1.0[YRI]
rs470011	intron_variant	0.894[CHB]; 0.906[CHD]
rs133937	intron_variant	0.853[CEU]; 0.954[GIH]; 0.865[MEX]
rs133965	intron_variant	0.961[CEU]; 0.947[CHB]; 0.89[JPT]; 1.0[YRI]
rs133959	intron_variant	0.961[CEU]; 0.947[CHB]; 0.89[JPT]; 1.0[YRI]
rs133938	intron_variant	0.853[CEU]
rs71699	intron_variant	0.948[CHB]; 0.822[CHD]; 0.841[JPT]
rs133942	intron_variant	0.948[CHB]; 0.906[CHD]; 0.836[JPT]
rs133931	intron_variant	0.814[CEU]
rs470008	intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.892[CHB]; 0.906[CHD]; 0.841[JPT]
rs5754377	intron_variant; upstream_gene_variant	0.917[CEU]; 0.826[JPT]
rs133934	intron_variant	0.851[CEU]
rs133962	intron_variant	0.894[CHB]
rs114509	intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs133944	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs133926	intron_variant	0.82[CEU]
rs1012082	intron_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]; 0.961[YRI]
rs133941	intron_variant	0.829[JPT]
rs133948	intron_variant; upstream_gene_variant	0.946[CHB]; 0.861[JPT]
rs739143	intron_variant	0.952[GIH]; 0.811[MEX]
rs133966	intron_variant	0.817[CEU]
rs78506	downstream_gene_variant; intron_variant; upstream_gene_variant	0.96[CEU]; 0.933[TSI]; 1.0[ASW]; 0.894[CHB]; 1.0[CHD]; 0.888[JPT]; 1.0[GIH]; 0.808[LWK]; 0.954[MEX]; 1.0[YRI]