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KEGG Pathway Report
Basic Info
| ID | hsa04115 |
|---|---|
| Name | p53 signaling pathway |
| Description | p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. |
| No. of Genes in ADHDgene | 14 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 14)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 14)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPRM | reprimo, TP53 dependent G2 arrest mediator candidate | 2q24.1 | Mapped by CNV |
| EI24 | etoposide induced 2.4 mRNA | 11q23 | Mapped by significant region |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 18q21.32 | Mapped by significant region |
| SESN3 | sestrin 3 | 11q21 | Mapped by significant region |
| TP53AIP1 | tumor protein p53 regulated apoptosis inducing protein 1 | 11q24.3 | Mapped by significant region |
| PERP | PERP, TP53 apoptosis effector | 6q24 | Mapped by significant region |
| RFWD2 | ring finger and WD repeat domain 2 | 1q25.1-q25.2 | Mapped by significant region |
| CYCS | cytochrome c, somatic | 7p21.2 | Mapped by CNV; Mapped by significant region |
| RRM2 | ribonucleotide reductase M2 | 2p25-p24 | Mapped by significant region |
| CHEK1 | CHK1 checkpoint homolog (S. pombe) | 11q24.2 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| ATM | ataxia telangiectasia mutated | 11q22-q23 | Mapped by CNV; Mapped by significant region |
| GADD45G | growth arrest and DNA-damage-inducible, gamma | 9q22.1-q22.2 | Mapped by significant region |
| RCHY1 | ring finger and CHY zinc finger domain containing 1 | 4q21.1-q21.3 | Mapped by CNV |