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KEGG Pathway Report
Basic Info
| ID | hsa04970 |
|---|---|
| Name | Salivary secretion |
| Description | Saliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for example. Salivary secretion occurs in response to stimulation by neurotransmitters released from autonomic nerve endings. There are two secretory pathways: protein exocytosis and fluid secretion. Sympathetic stimulation leads to the activation of adenylate cyclase and accumulation of intracellular cAMP. The elevation of cAMP causes the secretion of proteins such as amylase and mucin. In contrast, parasympathetic stimulation activates phospholipase C and causes the elevation of intracellular Ca2+, which leads to fluid secretion; that is, water and ion transport. Ca2+ also induces amylase secretion, but the amount is smaller than that induced by cAMP. |
| No. of Genes in ADHDgene | 22 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 22)
Literature-origin genes (count: 10)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ADRB1 | adrenergic, beta-1-, receptor | 10q24-q26 | 2(0/2/0) |
| ATP2B3 | ATPase, Ca++ transporting, plasma membrane 3 | Xq28 | 1(0/1/0) |
| VAMP2 | vesicle-associated membrane protein 2 (synaptobrevin 2) | 17pter-p12 | 2(0/2/0) |
| PRKG1 | protein kinase, cGMP-dependent, type I | 10q11.2 | 1(0/0/1) |
| ADRA1D | adrenergic, alpha-1D-, receptor | 20p13 | 1(0/1/0) |
| ADRB2 | adrenergic, beta-2-, receptor, surface | 5q31-q32 | 2(1/1/0) |
| NOS1 | nitric oxide synthase 1 (neuronal) | 12q14-qter | 1(1/0/0) |
| ADRA1B | adrenergic, alpha-1B-, receptor | 5q33.3 | 2(1/1/0) |
| ADRA1A | adrenergic, alpha-1A-, receptor | 8p21.2 | 3(2/1/0) |
| ADRB3 | adrenergic, beta-3-, receptor | 8p12 | 2(0/2/0) |
Genes from other sources (count: 12)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| RYR3 | ryanodine receptor 3 | 15q14-q15 | Mapped by CNV; Mapped by PBA pathway |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 11q23 | Mapped by significant region |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 | 7q34 | Mapped by PBA pathway |
| SLC4A2 | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) | 7q35-q36 | Mapped by LD-proxy; Mapped by literature SNP |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| GUCY1A2 | guanylate cyclase 1, soluble, alpha 2 | 11q21-q22 | Mapped by significant region |
| CHRM3 | cholinergic receptor, muscarinic 3 | 1q41-q44 | Mapped by CNV; Mapped by PBA pathway |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |