ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04145
Name Phagosome
Description  Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
No. of Genes in ADHDgene  32
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 32)

Literature-origin genes (count: 2)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 6p21.3 2(1/1/0)
NOS1 nitric oxide synthase 1 (neuronal) 12q14-qter 1(1/0/0)

Genes from other sources Help(count: 30)

Approved Symbol Approved Name Location Source
STX18 syntaxin 18 4 Mapped by PBA pathway
ATP6V1C2 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 2p25.1 Mapped by significant region
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 11q21-q22.1 Mapped by LD-proxy; Mapped by significant region
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 9q33.1 Mapped by significant region
CANX calnexin 5q35 Mapped by CNV
SCARB1 scavenger receptor class B, member 1 12q24.32 Mapped by CNV
TUBA4A tubulin, alpha 4a 2q36.1 Mapped by significant region
TLR4 toll-like receptor 4 9q33.1 Mapped by significant region
TUBB3 tubulin, beta 3 16q24.3 Mapped by significant region
TUBA3C tubulin, alpha 3c 13q12.11 Mapped by significant region
TUBA3E tubulin, alpha 3e 2q21.1 Mapped by significant region
STX7 syntaxin 7 6q23.1 Mapped by PBA pathway; Mapped by significant region
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 12q24.31 Mapped by CNV
ATP6V0D2 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 8q21.3 Mapped by CNV
COLEC12 collectin sub-family member 12 18pter-p11.3 Mapped by CNV
CORO1A coronin, actin binding protein, 1A 16p11.2 Mapped by CNV
CYBA cytochrome b-245, alpha polypeptide 16q24 Mapped by significant region
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 1q21.1 Mapped by PBA pathway
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 7q32.1 Mapped by LD-proxy
NCF2 neutrophil cytosolic factor 2 1q25 Mapped by significant region
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1q23 Mapped by CNV
PIK3C3 phosphoinositide-3-kinase, class 3 18q12.3 Mapped by significant region
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1q23 Mapped by CNV
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1q23 Mapped by CNV
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) 1q23 Mapped by CNV
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1q23 Mapped by CNV
TUBA3D tubulin, alpha 3d 2q21.1 Mapped by CNV; Mapped by significant region
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 11q13.2 Mapped by significant region
SEC61B Sec61 beta subunit 9q22.32-q31.3 Mapped by significant region
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 5q11.2 Mapped by LD-proxy

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014