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KEGG Pathway Report
Basic Info
| ID | hsa00010 |
|---|---|
| Name | Glycolysis / Gluconeogenesis |
| Description | Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabolites: six-carbon compounds of glucose-6P and fructose-6P and three-carbon compounds of glycerone-P, glyceraldehyde-3P, glycerate-3P, phosphoenolpyruvate, and pyruvate [MD:M00001]. Acetyl-CoA, another important precursor metabolite, is produced by oxidative decarboxylation of pyruvate [MD:M00307]. When the enzyme genes of this pathway are examined in completely sequenced genomes, the reaction steps of three-carbon compounds from glycerone-P to pyruvate form a conserved core module [MD:M00002], which is found in almost all organisms and which often corresponds to operon structures in bacterial genomes. Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. It is essentially a reversal of glycolysis with minor variations of alternative paths [MD:M00003]. |
| No. of Genes in ADHDgene | 11 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 11)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HK1 | hexokinase 1 | 10q22 | 1(0/1/0) |
| HKDC1 | hexokinase domain containing 1 | 10q22.1 | 1(0/1/0) |
Genes from other sources (count: 9)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| FBP2 | fructose-1,6-bisphosphatase 2 | 9q22.3 | Mapped by significant region |
| FBP1 | fructose-1,6-bisphosphatase 1 | 9q22.3 | Mapped by significant region |
| ALDOA | aldolase A, fructose-bisphosphate | 16p11.2 | Mapped by CNV |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 17p11.2 | Mapped by significant region |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | 17p11.2 | Mapped by significant region |
| DLAT | dihydrolipoamide S-acetyltransferase | 11q23.1 | Mapped by significant region |
| ALDOB | aldolase B, fructose-bisphosphate | 9q21.3-q22.2 | Mapped by significant region |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | 11q13 | Mapped by significant region |
| ALDH3B2 | aldehyde dehydrogenase 3 family, member B2 | 11q13 | Mapped by significant region |