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KEGG Pathway Report
Basic Info
| ID | hsa04623 |
|---|---|
| Name | Cytosolic DNA-sensing pathway |
| Description | Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. |
| No. of Genes in ADHDgene | 9 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 9)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 9)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| MAVS | mitochondrial antiviral signaling protein | 20p13 | Mapped by CNV |
| PYCARD | PYD and CARD domain containing | 16p11.2 | Mapped by CNV |
| RIPK3 | receptor-interacting serine-threonine kinase 3 | 14q12 | Mapped by significant region |
| CASP1 | caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) | 11q23 | Mapped by significant region |
| IRF7 | interferon regulatory factor 7 | 11p15.5 | Mapped by LD-proxy |
| POLR3E | polymerase (RNA) III (DNA directed) polypeptide E (80kD) | 16p12 | Mapped by CNV; Mapped by significant region |
| IL18 | interleukin 18 (interferon-gamma-inducing factor) | 11q22.2-q22.3 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |