ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol LPHN3
Symbol Alias KIAA0768, LEC3
Approved Name latrophilin 3
Location 4q13.1
Position chr4:62066976-62938184, +
External Links HGNC: 20974
Entrez Gene: 23284
Ensembl: ENSG00000150471
UCSC: uc010ihh.2
No. of Studies 4 (significant: 3; non-significant: 0; trend: 1)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region

Gene related studies (count: 4)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Ribases M, 2011 haplotype T-C-A, P-value=5.1e-05, df=1, OR=2.25; showed additional evidence of association between LPHN3 and combined type ADHD in adulthood Significant
Arcos-Burgos M, 2010 3 SNPs were significant after adjusting for multiple tests and 2 SNPs were potentially significant for the expression profile of LPHN3; a genome region harbored in the Latrophilin 3 gene (LPHN3) was discovered and statistical association was confirmed Significant
Jain, M., 2012 G(LPHN3)-G(rs677642, 11q)-G(rs877137, 11q), P-value<0.000005, OR(95%CI)=4.47(2.30-8.69); G(LPHN3)-else(11q), P-value(corrected)<0.005 in the case-control sample; Paisa: P-value=0.0027, OR(95%CI)=3.14(1.49-6.62) for C-GG haplotype; P-value=0.1661, OR(95%CI)=1.46(0.85-2.51) for G-else haplotype; P-value=0.0943, OR(95%CI)=0.73(0.51-1.06) for else-GG haplotype; German: P-value=0.0706, OR(95%CI)=1.91(0.95-3.84) for G-GG haplotype, P-value=0.6505, OR(95%CI)=1.11(0.72-1.71) for G-else haplotype; P-value=0.0449, OR(95%CI)=0.69(0.48-0.99) for else-GG haplotype; US1: P-value=0.1014, OR(95%CI)=3.1(0.8-1.2) for G-GG haplotype; P-value=0.5955, OR(95%CI)=1.23(0.58-2.59) for G-else haplotype; P-value=0.4139, OR(95%CI)=0.77(0.4-1.45) for else-GG haplotype; US2: P-value=0.0432, OR(95%CI)=2.28(1.03-5.08) for G-AG haplotype; P-value=0.2279, OR(95%CI)=0.82(0.59-1.13) for G-else haplotype; P-value=0.1306, OR(95%CI)=0.72(0.46-1.13) for else-AG haplotype; meta-analysis: interaction, P-value<0.00001; LPHN3 only, P-value=0.7111, P-value<0.001 for haplotype only. We focused on 4q-11q interaction to determine that single-nucleotide polymorphisms (SNPs) harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. Significant
Domene S, 2011 21 variants were identified, of which 14 have been reported and 7 are novel. These include 5 missense, 8 synonymous, and 8 intronic changes. a LPHN3 common haplotype confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Trend

Gene related SNPs (count: 123)

Literature-origin SNPs (count: 22)

LD-proxies (count: 101)

Gene related CNVs (count: 0)

Gene related other variant (count: 7)

Gene related regions (count: 1)

Gene related GO terms (count: 6)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 6)

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with LPHN3 (count: 3)

Genes shared at least 2 KEGG pathways with LPHN3 (count: 0)

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Region: chr4:62066976..62938184 View in gBrowse
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