ADHDgene Database

SNP Report

Basic Info

Name	rs2305339 dbSNP Ensembl
Location	Chr4:62800554(Fwd)
Variant Alleles	G/A
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant; splice_region_variant.
Consequence to Transcript	intron_variant(ENST00000512091; ENST00000511324; ENST00000509896; ENST00000514591; ENST00000507164; ENST00000506700; ENST00000508693; ENST00000514157; ENST00000507625; ENST00000508946; ENST00000504896; ENST00000502815; ENST00000506720; ENST00000514996; ENST00000506746; ENST00000508078; ENST00000545650) nc_transcript_variant(ENST00000508078) splice_region_variant(ENST00000512091; ENST00000511324; ENST00000509896; ENST00000514591; ENST00000507164; ENST00000506700; ENST00000508693; ENST00000507625; ENST00000514157; ENST00000508946; ENST00000504896; ENST00000502815; ENST00000506720; ENST00000514996; ENST00000506746; ENST00000508078; ENST00000545650)
No. of Studies	2 (significant: 0; non-significant: 0; trend: 2)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Arcos-Burgos M, 2010	A >G		mutation, no P-value mutation, no P-value	in the haplotype block associated with ADHD and located at ...... in the haplotype block associated with ADHD and located at splice sites, potential significance for the expression profile of LPHN3 More...	Trend
Domene S, 2011	c.1908-4G>A		Obs_HET/Pred_HET=0.462/0.429 Obs_HET/Pred_HET=0.462/0.429	neither susceptibility nor protective haplotype alleles are ...... neither susceptibility nor protective haplotype alleles are associated with obviously significant coding region changes, or canonical splice site alterations More...	Trend

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
LPHN3	latrophilin 3	4q13.1	4(3/0/1)

SNPs in LD with rs2305339 (count: 25) View in gBrowse (chr4:62759270..62844408 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs734644	nc_transcript_variant; non_coding_exon_variant; synonymous_variant	1(0/0/1)	1.0[ASW]; 1.0[CEU]; 0.829[CHB]; 0.881[CHD]; 1.0[GIH]; 0.907[JPT]; 0.921[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]

rs_ID	Functional Annotation	r²[population]
rs1470724	intron_variant	0.854[YRI]
rs10023425	intron_variant	0.832[CEU]
rs10020948	intron_variant; upstream_gene_variant	0.818[CHB]
rs11131347	intron_variant; upstream_gene_variant	0.821[CHB]
rs1397543	intron_variant	0.907[CHB]; 0.901[CHD]
rs10517549	intron_variant	0.86[ASW]; 0.911[CHB]; 0.88[CHD]; 0.882[GIH]; 0.953[JPT]; 0.874[MEX]; 0.981[MKK]; 0.87[TSI]; 0.951[YRI]
rs5012949	intron_variant	0.818[CHB]
rs1349408	intron_variant	0.854[YRI]
rs2122646	intron_variant; upstream_gene_variant	0.954[CEU]
rs7695892	intron_variant	0.821[CHB]
rs1376310	intron_variant	0.821[CHB]
rs6551669	intron_variant; upstream_gene_variant	0.863[CHB]
rs6843396	downstream_gene_variant; intron_variant	0.854[YRI]
rs1510925	intron_variant	1.0[CHB]; 0.927[CHD]; 0.864[JPT]; 0.869[MEX]
rs1450900	intron_variant	0.821[CHB]
rs1376309	intron_variant	0.821[CHB]
rs6551666	intron_variant	0.818[CHB]
rs6813183	intron_variant; upstream_gene_variant	0.863[CHB]
rs1355368	intron_variant	0.822[TSI]
rs10030755	intron_variant	0.863[CHB]; 0.903[CHD]; 0.813[JPT]; 0.867[MEX]
rs12503398	intron_variant	0.821[CHB]; 0.829[MEX]
rs17082493	intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]
rs4860442	downstream_gene_variant; intron_variant	0.86[CHB]
rs7690962	intron_variant	0.821[CHB]