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KEGG Pathway Report
Basic Info
| ID | hsa05140 |
|---|---|
| Name | Leishmaniasis |
| Description | Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses. |
| No. of Genes in ADHDgene | 14 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 14)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
Genes from other sources (count: 13)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| CYBA | cytochrome b-245, alpha polypeptide | 16q24 | Mapped by significant region |
| NCF2 | neutrophil cytosolic factor 2 | 1q25 | Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| FCGR3B | Fc fragment of IgG, low affinity IIIb, receptor (CD16b) | 1q23 | Mapped by CNV |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| FCGR3A | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) | 1q23 | Mapped by CNV |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| FCGR2A | Fc fragment of IgG, low affinity IIa, receptor (CD32) | 1q23 | Mapped by CNV |
| FCGR2C | Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) | 1q23 | Mapped by CNV |
| IFNGR1 | interferon gamma receptor 1 | 6q23-q24 | Mapped by significant region |