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KEGG Pathway Report
Basic Info
| ID | hsa05131 |
|---|---|
| Name | Shigellosis |
| Description | Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 13)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| WASL | Wiskott-Aldrich syndrome-like | 7q31.3 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| ARPC5L | actin related protein 2/3 complex, subunit 5-like | 9q34.11 | Mapped by significant region |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 1q | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| ATG5 | ATG5 autophagy related 5 homolog (S. cerevisiae) | 6q21 | Mapped by CNV |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 2q36.1 | Mapped by significant region |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | 21q22.3 | Mapped by PBA pathway |
| CTTN | cortactin | 11q13 | Mapped by significant region |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 2p24 | Mapped by significant region |