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KEGG Pathway Report
Basic Info
| ID | hsa05211 |
|---|---|
| Name | Renal cell carcinoma |
| Description | Renal cell cancer (RCC) accounts for ~3% of human malignancies and its incidence appears to be rising. Although most cases of RCC seem to occur sporadically, an inherited predisposition to renal cancer accounts for 1-4% of cases. RCC is not a single disease, it has several morphological subtypes. Conventional RCC (clear cell RCC) accounts for ~80% of cases, followed by papillary RCC (10-15%), chromophobe RCC (5%), and collecting duct RCC (<1%). Genes potentially involved in sporadic neoplasms of each particular type are VHL, MET, BHD, and FH respectively. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. Activated MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| TCEB1 | transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) | 8q13.3 | 1(0/0/1) |
| VEGFA | vascular endothelial growth factor A | 6p12 | 1(0/1/0) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| VEGFB | vascular endothelial growth factor B | 11q13 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 11q13-q14 | Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| ETS1 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | 11q23.3 | Mapped by significant region |
| FLCN | folliculin | 17p11.2 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| PAK7 | p21 protein (Cdc42/Rac)-activated kinase 7 | 20p12 | Mapped by CNV |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| EGLN3 | egl nine homolog 3 (C. elegans) | 14q12 | Mapped by LD-proxy; Mapped by literature SNP |