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KEGG Pathway Report
Basic Info
| ID | hsa05215 |
|---|---|
| Name | Prostate cancer |
| Description | Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
| CREB5 | cAMP responsive element binding protein 5 | 7p15 | 1(0/0/1) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| GSTP1 | glutathione S-transferase pi 1 | 11q13.2 | Mapped by significant region |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 17q11.2-q12 | Mapped by LD-proxy |
| PDGFD | platelet derived growth factor D | 11q22.3 | Mapped by significant region |
| INS | insulin | 11p15.5 | Mapped by literature SNP |