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KEGG Pathway Report
Basic Info
| ID | hsa04146 |
|---|---|
| Name | Peroxisome |
| Description | Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. |
| No. of Genes in ADHDgene | 9 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 9)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 9)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| BAAT | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) | 9q22.3 | Mapped by significant region |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | 12q24 | Mapped by CNV |
| PAOX | polyamine oxidase (exo-N4-amino) | 10q26.3 | Mapped by CNV |
| AMACR | alpha-methylacyl-CoA racemase | 5p13.2-q11.1 | Mapped by significant region |
| PECR | peroxisomal trans-2-enoyl-CoA reductase | 2q35 | Mapped by significant region |
| MLYCD | malonyl-CoA decarboxylase | 16q24 | Mapped by CNV; Mapped by significant region |
| PRDX5 | peroxiredoxin 5 | 11q13 | Mapped by significant region |
| PEX7 | peroxisomal biogenesis factor 7 | 6q21-q22.2 | Mapped by LD-proxy; Mapped by literature SNP; Mapped by significant region |
| MPV17L | MPV17 mitochondrial membrane protein-like | 16p13.11 | Mapped by CNV; Mapped by significant region |