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KEGG Pathway Report
Basic Info
| ID | hsa04340 |
|---|---|
| Name | Hedgehog signaling pathway |
| Description | The Hedgehog (Hh) family of secreted signaling proteins plays a crucial role in development of diverse animal phyla, from Drosophila to humans, regulating morphogenesis of a variety of tissues and organs. Hh signaling is also involved in control of stem cell proliferation in adult tissues and aberrant activation of the Hh pathway has been linked to multiple types of human cancer. Members of the Hh family bind to patched (ptc), thus releasing smoothened (smo) to transduce a signal. Transcriptional activation occurs through the GLI family of proteins resulting in activation of target genes. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CSNK1E | casein kinase 1, epsilon | 22q13.1 | 2(1/1/0) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 6)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| STK36 | serine/threonine kinase 36 | 2q35 | Mapped by significant region |
| WNT11 | wingless-type MMTV integration site family, member 11 | 11q13.5 | Mapped by significant region |
| WNT10A | wingless-type MMTV integration site family, member 10A | 2q35 | Mapped by significant region |
| IHH | Indian hedgehog | 2q33-q35 | Mapped by significant region |
| WNT6 | wingless-type MMTV integration site family, member 6 | 2q35 | Mapped by significant region |
| PTCH1 | patched 1 | 9q22.1-q31 | Mapped by significant region |