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KEGG Pathway Report
Basic Info
| ID | hsa04975 |
|---|---|
| Name | Fat digestion and absorption |
| Description | Fat is an important energy source from food. More than 95% of dietary fat is long-chain triacylglycerols (TAG), the remaining being phospholipids (4.5%) and sterols. In the small intestine lumen, dietary TAG is hydrolyzed to fatty acids (FA) and monoacylglycerols (MAG) by pancreatic lipase. These products are then emulsified with the help of phospholipids (PL) and bile acids (BA) present in bile to form micelles. Free FAs and MAGs are taken up by the enterocyte where they are rapidly resynthesized in endoplasmic reticulum (ER) to form TAG. PLs from the diet as well as bile - mainly LPA - too are absorbed by the enterocyte and are acylated to form phosphatidic acid (PA), which is also converted into TAG. Absorbed cholesterol (CL) is acylated to cholesterol esters (CE). Within the ER, TAG joins CE and apolipoprotein B (ApoB) to form chylomicrons that enter circulation through the lymph. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 1p35 | Mapped by PBA pathway |
| PLA2G1B | phospholipase A2, group IB (pancreas) | 12q23-qter | Mapped by PBA pathway |
| PLA2G2E | phospholipase A2, group IIE | 1p36.13 | Mapped by PBA pathway |
| PLA2G2D | phospholipase A2, group IID | 1p36.12 | Mapped by PBA pathway |
| PLA2G4B | phospholipase A2, group IVB (cytosolic) | 15q11.2-q21.3 | Mapped by PBA pathway |
| PLA2G3 | phospholipase A2, group III | 22q12.2 | Mapped by PBA pathway |
| PLA2G5 | phospholipase A2, group V | 1p36-p34 | Mapped by PBA pathway |
| MOGAT2 | monoacylglycerol O-acyltransferase 2 | 11q13.5 | Mapped by significant region |
| APOA1 | apolipoprotein A-I | 11q23-q24 | Mapped by significant region |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 9q31 | Mapped by CNV; Mapped by significant region |
| APOA4 | apolipoprotein A-IV | 11q23-qter | Mapped by significant region |
| PLA2G10 | phospholipase A2, group X | 16p13.1-p12 | Mapped by PBA pathway; Mapped by significant region |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 22q13.1 | Mapped by PBA pathway |
| DGAT2 | diacylglycerol O-acyltransferase 2 | 11q13.3 | Mapped by significant region |
| SCARB1 | scavenger receptor class B, member 1 | 12q24.32 | Mapped by CNV |
| PNLIP | pancreatic lipase | 10q25.3 | Mapped by PBA pathway |
| PNLIPRP1 | pancreatic lipase-related protein 1 | 10q26.12 | Mapped by PBA pathway |
| PNLIPRP2 | pancreatic lipase-related protein 2 | 10q26.12 | Mapped by PBA pathway |
| LIPF | lipase, gastric | 10q23 | Mapped by PBA pathway |