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KEGG Pathway Report
Basic Info
| ID | hsa05213 |
|---|---|
| Name | Endometrial cancer |
| Description | Endometrial cancer (EC) is the most common gynaecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification. |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 2p12-p11.1 | 2(1/1/0) |
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| APC | adenomatous polyposis coli | 5q21-q22 | Mapped by LD-proxy; Mapped by PBA pathway |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 10q21 | Mapped by CNV |
| ILK | integrin-linked kinase | 11p15.4 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 17q11.2-q12 | Mapped by LD-proxy |