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KEGG Pathway Report
Basic Info
| ID | hsa04976 |
|---|---|
| Name | Bile secretion |
| Description | Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 13)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| AQP4 | aquaporin 4 | 18q11.2-q12.1 | Mapped by significant region |
| UGT2B4 | UDP glucuronosyltransferase 2 family, polypeptide B4 | 4q13 | Mapped by significant region |
| SLC22A8 | solute carrier family 22 (organic anion transporter), member 8 | 11q12.3 | Mapped by significant region |
| SCTR | secretin receptor | 2q14.1 | Mapped by LD-proxy |
| SCARB1 | scavenger receptor class B, member 1 | 12q24.32 | Mapped by CNV |
| KCNN2 | potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 | 5q22.3 | Mapped by LD-proxy |
| BAAT | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) | 9q22.3 | Mapped by significant region |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 11q23 | Mapped by significant region |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 12p12 | Mapped by LD-proxy |
| SLC4A2 | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) | 7q35-q36 | Mapped by LD-proxy; Mapped by literature SNP |
| CA2 | carbonic anhydrase II | 8q22 | Mapped by CNV |
| ABCG2 | ATP-binding cassette, sub-family G (WHITE), member 2 | 4q22-q23 | Mapped by CNV |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |