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KEGG Pathway Report
Basic Info
| ID | hsa05217 |
|---|---|
| Name | Basal cell carcinoma |
| Description | Cancer of the skin is the most common cancer in Caucasians and basal cell carcinomas (BCC) account for 90% of all skin cancers. The vast majority of BCC cases are sporadic, though there is a rare familial syndrome basal cell nevus syndrome (BCNS, or Gorlin syndrome) that predisposes to development of BCC. In addition, there is strong epidemiological and genetic evidence that demonstrates UV exposure as a risk factor of prime importance. The development of basal cell carcinoma is associated with constitutive activation of sonic hedgehog signaling. The mutations in SMOH, PTCH1, and SHH in BCCs result in continuous activation of target genes. At a cellular level, sonic hedgehog signaling promotes cell proliferation. Mutations in TP53 are also found with high frequency (>50%) in sporadic BCC. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| APC | adenomatous polyposis coli | 5q21-q22 | Mapped by LD-proxy; Mapped by PBA pathway |
| STK36 | serine/threonine kinase 36 | 2q35 | Mapped by significant region |
| WNT11 | wingless-type MMTV integration site family, member 11 | 11q13.5 | Mapped by significant region |
| WNT10A | wingless-type MMTV integration site family, member 10A | 2q35 | Mapped by significant region |
| FZD4 | frizzled family receptor 4 | 11q14-q21 | Mapped by significant region |
| WNT6 | wingless-type MMTV integration site family, member 6 | 2q35 | Mapped by significant region |
| PTCH1 | patched 1 | 9q22.1-q31 | Mapped by significant region |