ADHDgene Database

SNP Report

Basic Info

Name	rs16976466 dbSNP Ensembl
Location	chr15:55972797(Fwd)
Variant Alleles	T/C
Ancestral Allele	T
Functional Annotation	missense_variant; nc_transcript_variant; non_coding_exon_variant; splice_region_variant; upstream_gene_variant. Polyphen Annotation: benign(ENST00000389286) SIFT Annotation: tolerated(ENST00000389286)
Consequence to Transcript	missense_variant(ENST00000389286) nc_transcript_variant(ENST00000561155) non_coding_exon_variant(ENST00000561155) splice_region_variant(ENST00000561155) upstream_gene_variant(ENST00000559842; ENST00000561465)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Wigg KG, 2008	G/A		TDT P-value=0.584, X²=0.3 TDT P-value=0.584, X²=0.3	no evidence for association no evidence for association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
PRTG	protogenin	15q21.3	1(1/0/0)

SNPs in LD with rs16976466 (count: 11) View in gBrowse (chr15:55967916..55998595 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs8031192	intron_variant	0.821[CHB]; 0.841[JPT]
rs1371056	intron_variant	0.9[JPT]
rs1530087	intron_variant	0.9[JPT]
rs9672390	intron_variant	0.817[CHB]; 0.829[JPT]
rs2118781	downstream_gene_variant; intron_variant; upstream_gene_variant	0.907[CEU]; 0.952[TSI]; 1.0[GIH]; 0.865[MEX]
rs12594642	intron_variant	0.9[JPT]
rs1014551	intron_variant	0.913[CEU]; 1.0[ASW]; 0.941[CHB]; 0.915[CHD]; 1.0[JPT]; 0.939[GIH]; 0.823[LWK]; 0.865[MEX]; 1.0[YRI]
rs687128	intron_variant	0.845[JPT]
rs1550330	intron_variant	0.838[JPT]
rs11858195	intron_variant	0.829[CHB]
rs7162071	intron_variant	0.824[CHB]; 0.897[JPT]