ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04977
Name Vitamin digestion and absorption
Description  Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma.
No. of Genes in ADHDgene  7
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 7)

Literature-origin genes (count: 0)

Genes from other sources Help(count: 7)

Approved Symbol Approved Name Location Source
GIF gastric intrinsic factor (vitamin B synthesis) 11 Mapped by significant region
PNLIP pancreatic lipase 10q25.3 Mapped by PBA pathway
CUBN cubilin (intrinsic factor-cobalamin receptor) 10p12 Mapped by CNV
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 16p13.1 Mapped by CNV; Mapped by significant region
APOA1 apolipoprotein A-I 11q23-q24 Mapped by significant region
APOA4 apolipoprotein A-IV 11q23-qter Mapped by significant region
SCARB1 scavenger receptor class B, member 1 12q24.32 Mapped by CNV