ADHDgene Database
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  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa04740
Name Olfactory transduction
Description  Within the compact cilia of the olfactory receptor neurons (ORNs) a cascade of enzymatic activity transduces the binding of an odorant molecule to a receptor into an electrical signal that can be transmitted to the brain. Odorant molecules bind to a receptor protein (R) coupled to an olfactory specific Gs-protein (G) and activate a type III adenylyl cyclase (AC), increasing intracellular cAMP levels. cAMP targets an olfactory-specific cyclic-nucleotide gated ion channel (CNG), allowing cations, particularly Na and Ca, to flow down their electrochemical gradients into the cell, depolarizing the ORN. Furthermore, the Ca entering the cell is able to activate a Ca-activated Cl channel, which would allow Cl to flow out of the cell, thus further increasing the depolarization. Elevated intracellular Ca causes adaptation by at least two different molecular steps: inhibition of the activity of adenylyl cyclase via CAMKII-dependent phosphorylation and down-regulation of the affinity of the CNG channel to cAMP.Longer exposure to odorants can stimulate particulate guanylyl cyclase in cilia to produce cGMP and activate PKG, leading to a further increase in amount and duration of intracellular cAMP levels, which may serve to convert inactive forms of protein kinase A (PKA2) to active forms (PKA*). As part of a feedback loop, PKA can inhibit the activation of particulate guanylyl cyclase.
No. of Genes in ADHDgene  173
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 173)

Literature-origin genes (count: 5)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend)
ADRBK2 adrenergic, beta, receptor kinase 2 22q11 1(0/1/0)
PRKG1 protein kinase, cGMP-dependent, type I 10q11.2 1(0/0/1)
OR4C3 olfactory receptor, family 4, subfamily C, member 3 11p11.2 1(0/0/1)
ARRB2 arrestin, beta 2 17p13 1(1/0/0)
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 18p11.22-p11.21 1(1/0/0)

Genes from other sources Help(count: 168)

Approved Symbol Approved Name Location Source
OR8K3 olfactory receptor, family 8, subfamily K, member 3 11q11 Mapped by CNV; Mapped by significant region
OR8K1 olfactory receptor, family 8, subfamily K, member 1 11q11 Mapped by CNV; Mapped by significant region
OR8J3 olfactory receptor, family 8, subfamily J, member 3 11q12.2 Mapped by CNV; Mapped by significant region
OR8J1 olfactory receptor, family 8, subfamily J, member 1 11q11 Mapped by CNV; Mapped by significant region
OR8I2 olfactory receptor, family 8, subfamily I, member 2 11q11 Mapped by CNV; Mapped by significant region
OR10G7 olfactory receptor, family 10, subfamily G, member 7 11q24.1 Mapped by significant region
OR8H3 olfactory receptor, family 8, subfamily H, member 3 11q11 Mapped by CNV; Mapped by significant region
OR8H2 olfactory receptor, family 8, subfamily H, member 2 11q11 Mapped by CNV; Mapped by significant region
OR10G4 olfactory receptor, family 10, subfamily G, member 4 11q24.1 Mapped by significant region
OR8H1 olfactory receptor, family 8, subfamily H, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5T3 olfactory receptor, family 5, subfamily T, member 3 11q11 Mapped by CNV; Mapped by significant region
OR10V1 olfactory receptor, family 10, subfamily V, member 1 11q12.1 Mapped by significant region
OR6A2 olfactory receptor, family 6, subfamily A, member 2 11p15.4 Mapped by CNV
OR5T1 olfactory receptor, family 5, subfamily T, member 1 11q11 Mapped by CNV; Mapped by significant region
OR6F1 olfactory receptor, family 6, subfamily F, member 1 1q44 Mapped by CNV
OR5T2 olfactory receptor, family 5, subfamily T, member 2 11q11 Mapped by CNV; Mapped by significant region
OR5M9 olfactory receptor, family 5, subfamily M, member 9 11q11 Mapped by CNV; Mapped by significant region
OR10S1 olfactory receptor, family 10, subfamily S, member 1 11q24.1 Mapped by significant region
OR5R1 olfactory receptor, family 5, subfamily R, member 1 11q11 Mapped by CNV; Mapped by significant region
OR10Q1 olfactory receptor, family 10, subfamily Q, member 1 11q12.1 Mapped by significant region
OR5M8 olfactory receptor, family 5, subfamily M, member 8 11q11 Mapped by CNV; Mapped by significant region
OR10G8 olfactory receptor, family 10, subfamily G, member 8 11q24.1 Mapped by significant region
OR56B4 olfactory receptor, family 56, subfamily B, member 4 11p15.4 Mapped by CNV
OR10G9 olfactory receptor, family 10, subfamily G, member 9 11q24.1 Mapped by significant region
OR5P3 olfactory receptor, family 5, subfamily P, member 3 11p15.4 Mapped by CNV
OR5M3 olfactory receptor, family 5, subfamily M, member 3 11q11 Mapped by CNV; Mapped by significant region
OR5M11 olfactory receptor, family 5, subfamily M, member 11 11q11 Mapped by CNV; Mapped by significant region
OR5M1 olfactory receptor, family 5, subfamily M, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5M10 olfactory receptor, family 5, subfamily M, member 10 11q11 Mapped by CNV; Mapped by significant region
OR13C4 olfactory receptor, family 13, subfamily C, member 4 9 Mapped by significant region
OR13C3 olfactory receptor, family 13, subfamily C, member 3 9 Mapped by significant region
OR13C8 olfactory receptor, family 13, subfamily C, member 8 9 Mapped by significant region
OR13C5 olfactory receptor, family 13, subfamily C, member 5 9 Mapped by significant region
OR52N5 olfactory receptor, family 52, subfamily N, member 5 11p15.4 Mapped by CNV
OR52N4 olfactory receptor, family 52, subfamily N, member 4 11p15.4 Mapped by CNV
OR13C2 olfactory receptor, family 13, subfamily C, member 2 9 Mapped by significant region
OR52N2 olfactory receptor, family 52, subfamily N, member 2 11p15.4 Mapped by CNV
OR52N1 olfactory receptor, family 52, subfamily N, member 1 11p15.4 Mapped by CNV
OR56B1 olfactory receptor, family 56, subfamily B, member 1 11p15.4 Mapped by CNV
OR13F1 olfactory receptor, family 13, subfamily F, member 1 9 Mapped by significant region
OR56A5 olfactory receptor, family 56, subfamily A, member 5 11p15.4 Mapped by CNV
OR1B1 olfactory receptor, family 1, subfamily B, member 1 9q33.2 Mapped by significant region
OR56A4 olfactory receptor, family 56, subfamily A, member 4 11p15.4 Mapped by CNV
OR13D1 olfactory receptor, family 13, subfamily D, member 1 9 Mapped by significant region
OR56A3 olfactory receptor, family 56, subfamily A, member 3 11p15.4 Mapped by CNV
OR13C9 olfactory receptor, family 13, subfamily C, member 9 9 Mapped by significant region
OR56A1 olfactory receptor, family 56, subfamily A, member 1 11p15.4 Mapped by CNV
OR52W1 olfactory receptor, family 52, subfamily W, member 1 11p15.4 Mapped by CNV
OR1L1 olfactory receptor, family 1, subfamily L, member 1 9 Mapped by significant region
OR1L3 olfactory receptor, family 1, subfamily L, member 3 9 Mapped by significant region
OR52B2 olfactory receptor, family 52, subfamily B, member 2 11p15.4 Mapped by CNV
OR1L4 olfactory receptor, family 1, subfamily L, member 4 9 Mapped by significant region
OR2Y1 olfactory receptor, family 2, subfamily Y, member 1 5q35 Mapped by CNV
OR1L6 olfactory receptor, family 1, subfamily L, member 6 9 Mapped by significant region
OR4C12 olfactory receptor, family 4, subfamily C, member 12 11p11.12 Mapped by CNV
OR1J1 olfactory receptor, family 1, subfamily J, member 1 9 Mapped by significant region
OR1J2 olfactory receptor, family 1, subfamily J, member 2 9 Mapped by significant region
OR1J4 olfactory receptor, family 1, subfamily J, member 4 9 Mapped by significant region
OR1K1 olfactory receptor, family 1, subfamily K, member 1 9 Mapped by significant region
OR2W3 olfactory receptor, family 2, subfamily W, member 3 1q44 Mapped by CNV
OR1S1 olfactory receptor, family 1, subfamily S, member 1 11q12.1 Mapped by significant region
OR1S2 olfactory receptor, family 1, subfamily S, member 2 11q12.1 Mapped by significant region
OR52M1 olfactory receptor, family 52, subfamily M, member 1 11p15.4 Mapped by CNV
OR2A4 olfactory receptor, family 2, subfamily A, member 4 6q23 Mapped by significant region
OR52E8 olfactory receptor, family 52, subfamily E, member 8 11p15.4 Mapped by CNV
OR52L1 olfactory receptor, family 52, subfamily L, member 1 11p15.4 Mapped by CNV
OR1L8 olfactory receptor, family 1, subfamily L, member 8 9 Mapped by significant region
OR52E6 olfactory receptor, family 52, subfamily E, member 6 11p15.4 Mapped by CNV
OR1N1 olfactory receptor, family 1, subfamily N, member 1 9q34.11 Mapped by significant region
OR8K5 olfactory receptor, family 8, subfamily K, member 5 11q11 Mapped by CNV; Mapped by significant region
OR1N2 olfactory receptor, family 1, subfamily N, member 2 9 Mapped by significant region
OR52E4 olfactory receptor, family 52, subfamily E, member 4 11p15.4 Mapped by CNV
OR1Q1 olfactory receptor, family 1, subfamily Q, member 1 9 Mapped by significant region
OR8U1 olfactory receptor, family 8, subfamily U, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5F1 olfactory receptor, family 5, subfamily F, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5I1 olfactory receptor, family 5, subfamily I, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5J2 olfactory receptor, family 5, subfamily J, member 2 11q11 Mapped by CNV; Mapped by significant region
OR5L2 olfactory receptor, family 5, subfamily L, member 2 11q11 Mapped by CNV; Mapped by significant region
OR5L1 olfactory receptor, family 5, subfamily L, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5D14 olfactory receptor, family 5, subfamily D, member 14 11q11 Mapped by CNV; Mapped by significant region
OR5D13 olfactory receptor, family 5, subfamily D, member 13 11q11 Mapped by CNV; Mapped by significant region
OR5D16 olfactory receptor, family 5, subfamily D, member 16 11q11 Mapped by CNV; Mapped by significant region
OR5D18 olfactory receptor, family 5, subfamily D, member 18 11q11 Mapped by CNV; Mapped by significant region
OR5AP2 olfactory receptor, family 5, subfamily AP, member 2 11q11 Mapped by CNV; Mapped by significant region
OR5AR1 olfactory receptor, family 5, subfamily AR, member 1 11q11 Mapped by CNV; Mapped by significant region
OR5AS1 olfactory receptor, family 5, subfamily AS, member 1 11q11 Mapped by CNV; Mapped by significant region
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 11q11 Mapped by CNV; Mapped by significant region
OR9I1 olfactory receptor, family 9, subfamily I, member 1 11q12.1 Mapped by significant region
OR9G4 olfactory receptor, family 9, subfamily G, member 4 11q11 Mapped by significant region
OR9Q2 olfactory receptor, family 9, subfamily Q, member 2 11q12.1 Mapped by significant region
OR9Q1 olfactory receptor, family 9, subfamily Q, member 1 11q12.1 Mapped by significant region
CAMK2D calcium/calmodulin-dependent protein kinase II delta 4q26 Mapped by CNV
OR8G5 olfactory receptor, family 8, subfamily G, member 5 11q24.1 Mapped by significant region
OR9G1 olfactory receptor, family 9, subfamily G, member 1 11q11 Mapped by significant region
OR8D2 olfactory receptor, family 8, subfamily D, member 2 11q24.1 Mapped by significant region
OR8D4 olfactory receptor, family 8, subfamily D, member 4 11q24.1 Mapped by significant region
OR8D1 olfactory receptor, family 8, subfamily D, member 1 11q25 Mapped by significant region
OR8G2 olfactory receptor, family 8, subfamily G, member 2 11q24.2 Mapped by significant region
OR8G1 olfactory receptor, family 8, subfamily G, member 1 11q24.2 Mapped by significant region
OR8B4 olfactory receptor, family 8, subfamily B, member 4 11q24 Mapped by significant region
OR8B8 olfactory receptor, family 8, subfamily B, member 8 11q24.2 Mapped by significant region
OR8A1 olfactory receptor, family 8, subfamily A, member 1 11q24.2 Mapped by significant region
OR8B12 olfactory receptor, family 8, subfamily B, member 12 11 Mapped by significant region
CNGA4 cyclic nucleotide gated channel alpha 4 11p15.4 Mapped by CNV
OR6Q1 olfactory receptor, family 6, subfamily Q, member 1 11q12.1 Mapped by significant region
OR6T1 olfactory receptor, family 6, subfamily T, member 1 11q24.1 Mapped by significant region
OR6X1 olfactory receptor, family 6, subfamily X, member 1 11q24.1 Mapped by significant region
OR5C1 olfactory receptor, family 5, subfamily C, member 1 9q34.2 Mapped by significant region
OR6M1 olfactory receptor, family 6, subfamily M, member 1 11q24.1 Mapped by significant region
OR2AG2 olfactory receptor, family 2, subfamily AG, member 2 11p15.4 Mapped by CNV
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 11p15.4 Mapped by CNV
OR1C1 olfactory receptor, family 1, subfamily C, member 1 1q44 Mapped by CNV
OR2C3 olfactory receptor, family 2, subfamily C, member 3 1q44 Mapped by CNV
OR2AK2 olfactory receptor, family 2, subfamily AK, member 2 1q44 Mapped by CNV
OR5B3 olfactory receptor, family 5, subfamily B, member 3 11q12.1 Mapped by significant region
OR5B21 olfactory receptor, family 5, subfamily B, member 21 11q12.1 Mapped by significant region
OR13G1 olfactory receptor, family 13, subfamily G, member 1 1q44 Mapped by CNV
OR11L1 olfactory receptor, family 11, subfamily L, member 1 1 Mapped by CNV
OR10A6 olfactory receptor, family 10, subfamily A, member 6 11p15.4 Mapped by CNV
OR10A5 olfactory receptor, family 10, subfamily A, member 5 11p15.4 Mapped by CNV
OR5B17 olfactory receptor, family 5, subfamily B, member 17 11q12.1 Mapped by significant region
OR14A16 olfactory receptor, family 14, subfamily A, member 16 1q44 Mapped by CNV
OR5B12 olfactory receptor, family 5, subfamily B, member 12 11q12.1 Mapped by significant region
OR2M3 olfactory receptor, family 2, subfamily M, member 3 1q44 Mapped by CNV
OR2M4 olfactory receptor, family 2, subfamily M, member 4 1q44 Mapped by CNV
OR5AN1 olfactory receptor, family 5, subfamily AN, member 1 11q12.1 Mapped by significant region
OR2M2 olfactory receptor, family 2, subfamily M, member 2 1q44 Mapped by CNV
OR2T33 olfactory receptor, family 2, subfamily T, member 33 1q44 Mapped by CNV
OR2T8 olfactory receptor, family 2, subfamily T, member 8 1q44 Mapped by CNV
OR2M5 olfactory receptor, family 2, subfamily M, member 5 1q44 Mapped by CNV
OR5AK2 olfactory receptor, family 5, subfamily AK, member 2 11q11 Mapped by significant region
OR2T12 olfactory receptor, family 2, subfamily T, member 12 1q44 Mapped by CNV
OR5A1 olfactory receptor, family 5, subfamily A, member 1 11q12.1 Mapped by significant region
OR2G2 olfactory receptor, family 2, subfamily G, member 2 1q44 Mapped by CNV
OR5A2 olfactory receptor, family 5, subfamily A, member 2 11q12.1 Mapped by significant region
OR2G3 olfactory receptor, family 2, subfamily G, member 3 1q44 Mapped by CNV
OR2D2 olfactory receptor, family 2, subfamily D, member 2 11p15.4 Mapped by CNV
OR2D3 olfactory receptor, family 2, subfamily D, member 3 11p15.4 Mapped by CNV
OR2L3 olfactory receptor, family 2, subfamily L, member 3 1q44 Mapped by CNV
OR4S2 olfactory receptor, family 4, subfamily S, member 2 11q11 Mapped by significant region
OR2L8 olfactory receptor, family 2, subfamily L, member 8 1q44 Mapped by CNV
OR2L13 olfactory receptor, family 2, subfamily L, member 13 1q44 Mapped by CNV
OR4P4 olfactory receptor, family 4, subfamily P, member 4 11q11 Mapped by significant region
OR2L2 olfactory receptor, family 2, subfamily L, member 2 1q44 Mapped by CNV
OR4M2 olfactory receptor, family 4, subfamily M, member 2 15 Mapped by significant region
OR4N4 olfactory receptor, family 4, subfamily N, member 4 15q11.2 Mapped by significant region
OR4D6 olfactory receptor, family 4, subfamily D, member 6 11q12.1 Mapped by significant region
OR4D9 olfactory receptor, family 4, subfamily D, member 9 11q12.1 Mapped by significant region
OR4D10 olfactory receptor, family 4, subfamily D, member 10 11q12.1 Mapped by significant region
OR4C6 olfactory receptor, family 4, subfamily C, member 6 11q11 Mapped by significant region
OR4D5 olfactory receptor, family 4, subfamily D, member 5 11q24.1 Mapped by significant region
OR4D11 olfactory receptor, family 4, subfamily D, member 11 11q12.1 Mapped by significant region
OR4C15 olfactory receptor, family 4, subfamily C, member 15 11q11 Mapped by significant region
OR4C16 olfactory receptor, family 4, subfamily C, member 16 11q11 Mapped by significant region
OR4B1 olfactory receptor, family 4, subfamily B, member 1 11p11.2 Mapped by LD-proxy
OR4C11 olfactory receptor, family 4, subfamily C, member 11 11q11 Mapped by significant region
OR4A15 olfactory receptor, family 4, subfamily A, member 15 11q11 Mapped by significant region
OR10A2 olfactory receptor, family 10, subfamily A, member 2 11p15.4 Mapped by CNV
OR4A16 olfactory receptor, family 4, subfamily A, member 16 11q11 Mapped by significant region
OR10A3 olfactory receptor, family 10, subfamily A, member 3 11p15.4 Mapped by CNV
OR4A47 olfactory receptor, family 4, subfamily A, member 47 11p11.2 Mapped by LD-proxy
OR10A4 olfactory receptor, family 10, subfamily A, member 4 11p15.4 Mapped by CNV
OR4X1 olfactory receptor, family 4, subfamily X, member 1 11p11.2 Mapped by LD-proxy
OR4X2 olfactory receptor, family 4, subfamily X, member 2 11p11.2 Mapped by LD-proxy
OR4C45 olfactory receptor, family 4, subfamily C, member 45 11p11.12 Mapped by LD-proxy
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 11q13.4 Mapped by significant region
OR2K2 olfactory receptor, family 2, subfamily K, member 2 9q31.3 Mapped by significant region
OR4S1 olfactory receptor, family 4, subfamily S, member 1 11p11.2 Mapped by LD-proxy

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014