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KEGG Pathway Report
Basic Info
| ID | hsa04914 |
|---|---|
| Name | Progesterone-mediated oocyte maturation |
| Description | Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 13)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| PLK1 | polo-like kinase 1 | 16p | Mapped by significant region |
| CDC26 | cell division cycle 26 homolog (S. cerevisiae) | 9q32 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| ANAPC4 | anaphase promoting complex subunit 4 | 4p15.31 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| PGR | progesterone receptor | 11q22-q23 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| CDC25B | cell division cycle 25 homolog B (S. pombe) | 20p13 | Mapped by CNV |
| SPDYC | speedy homolog C (Xenopus laevis) | 11q13.1 | Mapped by significant region |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |
| INS | insulin | 11p15.5 | Mapped by literature SNP |