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KEGG Pathway Report
Basic Info
| ID | hsa05130 |
|---|---|
| Name | Pathogenic Escherichia coli infection |
| Description | Eenteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction of attaching and effacing (A/E) lesions that damage intestinal epithelial cells. The capacity to form A/E lesions is encoded mainly by the locus of enterocyte effacement (LEE) pathogenicity island. Tir, Map, EspF, EspG are known LEE-encoded effector proteins secreted via the type III secretion system, which is also LEE-encoded, into the host cell. EPEC and EHEC Tir's link the extracellular bacterium to the cell cytoskeleton. Map and EspF are involved in mitochondrion membrane permeabilization. EspG interacts with tubulins and stimulates microtubule destabilization. LEE-encoded adhesin or intimin (Eae) is exported via the general secretory pathway to the periplasm, where it is inserted into the outer membrane. In addition to Tir, two potential host cell-carried intimin receptors, beta1 integrin (ITGB1) and nucleolin (NCL), have so far been identified. The distinguishing feature of EHEC is the elaboration of Shiga-like toxin (Stx). Stx cleaves ribosomal RNA, thereby disrupting protein synthesis and killing the intoxicated epithelial or endothelial cells. |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 17)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 17)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| WASL | Wiskott-Aldrich syndrome-like | 7q31.3 | Mapped by CNV |
| ARPC5L | actin related protein 2/3 complex, subunit 5-like | 9q34.11 | Mapped by significant region |
| NCK1 | NCK adaptor protein 1 | 3q21 | Mapped by PBA pathway |
| NCK2 | NCK adaptor protein 2 | 2q12 | Mapped by PBA pathway |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | 1q | Mapped by significant region |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | 2p25.2-p25.1 | Mapped by significant region |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 2q36.1 | Mapped by significant region |
| TUBA4A | tubulin, alpha 4a | 2q36.1 | Mapped by significant region |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 1q21-q22 | Mapped by PBA pathway |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| KRT18 | keratin 18 | 12q13 | Mapped by PBA pathway |
| TUBB3 | tubulin, beta 3 | 16q24.3 | Mapped by significant region |
| TUBA3D | tubulin, alpha 3d | 2q21.1 | Mapped by CNV; Mapped by significant region |
| TUBA3C | tubulin, alpha 3c | 13q12.11 | Mapped by significant region |
| TUBA3E | tubulin, alpha 3e | 2q21.1 | Mapped by significant region |
| CTTN | cortactin | 11q13 | Mapped by significant region |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 2p24 | Mapped by significant region |