ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

KEGG Pathway Report

Basic Info

ID	hsa04142
Name	Lysosome
Description	Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
No. of Genes in ADHDgene	19
Source	Pathway by Database Search

Pathway related genes in ADHDgene (count: 19)

Literature-origin genes (count: 0)

Genes from other sources (count: 19)

Approved Symbol	Approved Name	Location	Source
NPC1	Niemann-Pick disease, type C1	18q11-q12	Mapped by significant region
SMPD1	sphingomyelin phosphodiesterase 1, acid lysosomal	11p15.4-p15.1	Mapped by CNV; Mapped by PBA pathway
SUMF1	sulfatase modifying factor 1	3p26.1	Mapped by CNV
TPP1	tripeptidyl peptidase I	11p15.4	Mapped by CNV
AP3B2	adaptor-related protein complex 3, beta 2 subunit	15q	Mapped by PBA pathway
CLTCL1	clathrin, heavy chain-like 1	22q11.2	Mapped by CNV
GGA2	golgi-associated, gamma adaptin ear containing, ARF binding protein 2	16p12	Mapped by significant region
AP4S1	adaptor-related protein complex 4, sigma 1 subunit	14q12	Mapped by significant region
SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	2q35	Mapped by significant region
CTSC	cathepsin C	11q14.2	Mapped by significant region
CTSF	cathepsin F	11q13.2	Mapped by significant region
CTSG	cathepsin G	14q12	Mapped by significant region
CTSL2	cathepsin L2	9q22.33	Mapped by significant region
SORT1	sortilin 1	1p13.3	Mapped by CNV
TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	11q13.2	Mapped by significant region
CTSW	cathepsin W	11q13.1	Mapped by significant region
ATP6V0A2	ATPase, H+ transporting, lysosomal V0 subunit a2	12q24.31	Mapped by CNV
GALNS	galactosamine (N-acetyl)-6-sulfate sulfatase	16q24.3	Mapped by significant region
ATP6V0D2	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	8q21.3	Mapped by CNV