Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa05221 |
|---|---|
| Name | Acute myeloid leukemia |
| Description | Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated. |
| No. of Genes in ADHDgene | 10 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 10)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 11q13.1 | Mapped by significant region |
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| ZBTB16 | zinc finger and BTB domain containing 16 | 11q23 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| SPI1 | spleen focus forming virus (SFFV) proviral integration oncogene spi1 | 11p12-p11.22 | Mapped by LD-proxy |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |