ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs10807124 dbSNP Ensembl
Location	chr6:33404064(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000293748; ENST00000418600; ENST00000428982; ENST00000449372; ENST00000479510; ENST00000496374) nc_transcript_variant(ENST00000479510; ENST00000496374) upstream_gene_variant(ENST00000495633; ENST00000579078)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lantieri F, 2010	A:G		Binomial P-value=0.89, OR=1.14 for whole sample; Binomial P-...... Binomial P-value=0.89, OR=1.14 for whole sample; Binomial P-value=0.8, OR=1.12 for C-subtype More...	no significant association no significant association	Non-significant
Neale BM, 2008	A:G		Uncorrected TDT P-value=6.71E-05 (OR=0.7435) Uncorrected TDT P-value=6.71E-05 (OR=0.7435)	One of top 25 results in uncorrected TDT test One of top 25 results in uncorrected TDT test	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
SYNGAP1	synaptic Ras GTPase activating protein 1	6p21.3

SNPs in LD with rs10807124 (count: 20) View in gBrowse (chr6:33280309..33534880 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 20)

rs_ID	Functional Annotation	r²[population]
rs465474	upstream_gene_variant	0.865[GIH]; 0.875[MEX]
rs9394145	intron_variant; missense_variant; nc_transcript_variant	0.945[CEU]; 1.0[TSI]; 1.0[ASW]; 1.0[CHB]; 1.0[CHD]; 0.903[JPT]; 0.976[GIH]; 1.0[MEX]
rs6914422		0.829[CHB]
rs2239839	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.861[ASW]; 0.827[MEX]; 1.0[MKK]
rs2282851	downstream_gene_variant; intron_variant; nc_transcript_variant	0.861[ASW]; 0.827[MEX]; 1.0[MKK]
rs9380355	downstream_gene_variant	0.817[CHD]; 0.865[GIH]; 0.915[MEX]
rs1755047		0.842[CHB]; 0.865[GIH]; 0.838[MEX]
rs6942045		0.887[CEU]; 0.973[TSI]; 0.861[ASW]; 1.0[CHB]; 0.97[CHD]; 0.91[JPT]; 1.0[GIH]; 0.956[MEX]
rs442745	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	0.865[GIH]; 0.875[MEX]
rs2772373	downstream_gene_variant	0.886[GIH]; 0.838[MEX]
rs9380365		0.941[CHB]; 0.91[JPT]
rs2772387		0.842[CHB]
rs3130276	upstream_gene_variant	0.814[GIH]; 0.875[MEX]
rs3106191	downstream_gene_variant; intron_variant; nc_transcript_variant	0.861[ASW]; 0.827[MEX]; 1.0[MKK]
rs9366824		0.829[CHB]
rs461964	downstream_gene_variant; intron_variant; upstream_gene_variant	0.825[GIH]; 0.875[MEX]
rs3130275	downstream_gene_variant	0.861[ASW]; 0.875[MEX]
rs1059231	downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	0.861[ASW]; 0.821[MEX]; 1.0[MKK]
rs456993	upstream_gene_variant	0.865[GIH]; 0.875[MEX]
rs465506	upstream_gene_variant	0.825[GIH]; 0.875[MEX]