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KEGG Pathway Report
Basic Info
| ID | hsa05323 |
|---|---|
| Name | Rheumatoid arthritis |
| Description | Rheumatoid arthritis (RA) is a chronic autoimmune joint disease where persistent inflammation affects bone remodeling leading to progressive bone destruction. In RA, abnormal activation of the immune system elevates pro-inflammatory cytokines and chemokines levels, which can promote synovial angiogenesis and leukocyte infiltration. The synovium forms a hyperplastic pannus with infiltrated macrophage-like and fibroblast-like synoviocytes and invades joints by secreting proteinases and inducing osteoclast differentiation. |
| No. of Genes in ADHDgene | 17 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 17)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| VEGFA | vascular endothelial growth factor A | 6p12 | 1(0/1/0) |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
Genes from other sources (count: 15)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| ITGAL | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) | 16p13.1-p11 | Mapped by CNV |
| VEGFB | vascular endothelial growth factor B | 11q13 | Mapped by significant region |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 2p25.1 | Mapped by significant region |
| TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | 18q22.1 | Mapped by CNV |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 9q33.1 | Mapped by significant region |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 7q32.1 | Mapped by LD-proxy |
| IL18 | interleukin 18 (interferon-gamma-inducing factor) | 11q22.2-q22.3 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| MMP1 | matrix metallopeptidase 1 (interstitial collagenase) | 11q21-q22 | Mapped by significant region |
| TLR4 | toll-like receptor 4 | 9q33.1 | Mapped by significant region |
| MMP3 | matrix metallopeptidase 3 (stromelysin 1, progelatinase) | 11q22.3 | Mapped by significant region |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 10q11.1 | Mapped by PBA pathway |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 11q13.2 | Mapped by significant region |
| ATP6V0A2 | ATPase, H+ transporting, lysosomal V0 subunit a2 | 12q24.31 | Mapped by CNV |
| ATP6V0D2 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 8q21.3 | Mapped by CNV |