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KEGG Pathway Report
Basic Info
| ID | hsa04961 |
|---|---|
| Name | Endocrine and other factor-regulated calcium reabsorption |
| Description | Calcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. In kidney, the late part of the distal convoluted tubule (DCT) and the connecting tubule (CNT) are the site of active Ca2+ transport and precisely regulate Ca2+ reabsorption. Following Ca2+ entry through TRPV5, Ca2+ bound to calbindin-D28K diffuses to the basolateral side, where it is extruded into the blood compartment through NCX1 and to a lesser extent PMCA1b. In the urinary compartment, both klotho and tissue kallikrein (TK) increase the apical abundance of TRPV5. In the blood compartment, PTH, 1,25(OH)2D3 and estrogen increase the transcription and protein expression of the luminal Ca2+ channels, calbindins, and the extrusion systems. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| DNM1 | dynamin 1 | 9q34 | 1(0/0/1) |
Genes from other sources (count: 7)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 11q23 | Mapped by significant region |
| TRPV5 | transient receptor potential cation channel, subfamily V, member 5 | 7q34 | Mapped by PBA pathway |
| BDKRB2 | bradykinin receptor B2 | 14q32.1-q32.2 | Mapped by PBA pathway |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| CLTCL1 | clathrin, heavy chain-like 1 | 22q11.2 | Mapped by CNV |