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KEGG Pathway Report
Basic Info
| ID | hsa04012 |
|---|---|
| Name | ErbB signaling pathway |
| Description | The ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including proliferation, differentiation, cell motility, and survival. Ligand binding to the four closely related members of this RTK family -epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4)-induces the formation of receptor homo- and heterodimers and the activation of the intrinsic kinase domain, resulting in phosphorylation on specific tyrosine residues (pY) within the cytoplasmic tail. Signaling effectors containing binding pockets for pY-containing peptides are recruited to activated receptors and induce the various signaling pathways. The Shc- and/or Grb2-activated mitogen-activated protein kinase (MAPK) pathway is a common target downstream of all ErbB receptors. Similarly, the phosphatidylinositol-3-kinase (PI-3K) pathway is directly or indirectly activated by most ErbBs. Several cytoplasmic docking proteins appear to be recruited by specific ErbB receptors and less exploited by others. These include the adaptors Crk, Nck, the phospholipase C gamma (PLCgamma), the intracellular tyrosine kinase Src, or the Cbl E3 ubiquitin protein ligase. |
| No. of Genes in ADHDgene | 21 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 21)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
| EREG | epiregulin | 4q21.21 | 1(0/0/1) |
Genes from other sources (count: 19)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 11q13.1 | Mapped by significant region |
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 11q13-q14 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 4q26 | Mapped by CNV |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11q23.3-qter | Mapped by significant region |
| BTC | betacellulin | 4q13-q21 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 9q22.1 | Mapped by significant region |
| NCK1 | NCK adaptor protein 1 | 3q21 | Mapped by PBA pathway |
| NCK2 | NCK adaptor protein 2 | 2q12 | Mapped by PBA pathway |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| PAK7 | p21 protein (Cdc42/Rac)-activated kinase 7 | 20p12 | Mapped by CNV |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 16q24.1 | Mapped by significant region |
| ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 17q11.2-q12 | Mapped by LD-proxy |