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KEGG Pathway Report
Basic Info
| ID | hsa05110 |
|---|---|
| Name | Vibrio cholerae infection |
| Description | Cholera toxin (CTX) is one of the main virulence factors of Vibrio cholerae. Once secreted, CTX B-chain (CTXB) binds to ganglioside GM1 on the surface of the host's cells. After binding takes place, the entire CTX complex is carried from plasma membrane (PM) to endoplasmic reticulum (ER). In the ER, the A-chain (CTXA) is recognized by protein disulfide isomerase (PDI), unfolded, and delivered to the membrane where the membrane-associated ER-oxidase, Ero1, oxidizes PDI to release the CTXA into the protein-conducting channel, Sec61. CTXA is then retro-translocated to the cytosol and induces water and electrolyte secretion by increasing cAMP levels via adenylate cyclase (AC) to exert toxicity. |
| No. of Genes in ADHDgene | 10 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 10)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| ATP6V1C2 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2 | 2p25.1 | Mapped by significant region |
| TJP1 | tight junction protein 1 (zona occludens 1) | 15q13 | Mapped by CNV; Mapped by significant region |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | 9q33.1 | Mapped by significant region |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | 7q32.1 | Mapped by LD-proxy |
| TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 11q13.2 | Mapped by significant region |
| PLCG2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | 16q24.1 | Mapped by significant region |
| ATP6V0A2 | ATPase, H+ transporting, lysosomal V0 subunit a2 | 12q24.31 | Mapped by CNV |
| SEC61B | Sec61 beta subunit | 9q22.32-q31.3 | Mapped by significant region |
| ATP6V0D2 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 | 8q21.3 | Mapped by CNV |