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KEGG Pathway Report
Basic Info
| ID | hsa04974 |
|---|---|
| Name | Protein digestion and absorption |
| Description | Protein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancreatic and small intestinal enzymes. The result of this proteolytic activity is a mixture of amino acids and small peptides. Amino acids (AAs) are transported into the enterocyte (intestinal epithelial cell) by a variety of AA transporters that are specific for cationic (basic) AA, neutral AA, and anionic (acidic) AA. Small peptides are absorbed into enterocytes by the PEPT1 transporter. Inside enterocytes peptides are hydrolyzed, and the resulting amino acids are released together with those absorbed by AA transporters into blood via multiple, basolateral, AA transporters. Hydrolysis-resistant peptides, however, are transported out of the cells by a basolateral peptide transporter that has not been identified molecularly. |
| No. of Genes in ADHDgene | 10 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 10)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| COL15A1 | collagen, type XV, alpha 1 | 9q21-q22 | Mapped by significant region |
| PGA5 | pepsinogen 5, group I (pepsinogen A) | 11q13 | Mapped by significant region |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 11q23 | Mapped by significant region |
| PGA3 | pepsinogen 3, group I (pepsinogen A) | 11q13 | Mapped by significant region |
| PGA4 | pepsinogen 4, group I (pepsinogen A) | 11q13 | Mapped by significant region |
| MEP1B | meprin A, beta | 18q12.2-q12.3 | Mapped by significant region |
| CTRB1 | chymotrypsinogen B1 | 16q23.1 | Mapped by significant region |
| PRCP | prolylcarboxypeptidase (angiotensinase C) | 11q14 | Mapped by significant region |
| KCNE3 | potassium voltage-gated channel, Isk-related family, member 3 | 11q13.4 | Mapped by significant region |
| SLC3A2 | solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 | 11q12-q22 | Mapped by significant region |