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KEGG Pathway Report
Basic Info
| ID | hsa03420 |
|---|---|
| Name | Nucleotide excision repair |
| Description | Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar. |
| No. of Genes in ADHDgene | 9 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 9)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 9)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| GTF2H3 | general transcription factor IIH, polypeptide 3, 34kDa | 12q24.31 | Mapped by CNV |
| DDB1 | damage-specific DNA binding protein 1, 127kDa | 11q12-q13 | Mapped by significant region |
| ERCC8 | excision repair cross-complementing rodent repair deficiency, complementation group 8 | 5q12.1 | Mapped by CNV |
| POLE | polymerase (DNA directed), epsilon | 12q24.3 | Mapped by CNV |
| POLD3 | polymerase (DNA-directed), delta 3, accessory subunit | 11q14 | Mapped by significant region |
| POLD4 | polymerase (DNA-directed), delta 4 | 11q13 | Mapped by significant region |
| XPA | xeroderma pigmentosum, complementation group A | 9q22.3 | Mapped by significant region |
| POLE3 | polymerase (DNA directed), epsilon 3 (p17 subunit) | 9q33 | Mapped by significant region |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 9q31.2 | Mapped by significant region |