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KEGG Pathway Report
Basic Info
| ID | hsa04640 |
|---|---|
| Name | Hematopoietic cell lineage |
| Description | Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes. |
| No. of Genes in ADHDgene | 13 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 13)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ITGA1 | integrin, alpha 1 | 5q11.1 | 1(0/1/0) |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
Genes from other sources (count: 11)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| IL7R | interleukin 7 receptor | 5p13 | Mapped by significant region |
| CD5 | CD5 molecule | 11q13 | Mapped by significant region |
| CD3G | CD3g molecule, gamma (CD3-TCR complex) | 11q23 | Mapped by significant region |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 11q23 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |
| CD3D | CD3d molecule, delta (CD3-TCR complex) | 11q23 | Mapped by significant region |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 11q12-q13.1 | Mapped by significant region |
| GP1BB | glycoprotein Ib (platelet), beta polypeptide | 22q11.21-q11.23 | Mapped by CNV |
| IL5RA | interleukin 5 receptor, alpha | 3p26-p24 | Mapped by CNV |
| IL11RA | interleukin 11 receptor, alpha | 9p13 | Mapped by LD-proxy |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 5q11.2 | Mapped by LD-proxy |