ADHDgene Database
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Type:
  • Large-scale studies
  • Data Summary
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

KEGG Pathway Report

Basic Info
ID hsa00563
Name Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Description  Cell surface proteins can be attached to the cell membrane via the glycolipid structure called glycosylphosphatidylinositol (GPI) anchor. Hundreds of GPI-anchored proteins have been identified in many eukaryotes ranging from protozoa and fungi to mammals. All protein-linked GPI anchors share a common core structure, characterized by the substructure Man (a1-4) GlcN (a1-6) myo-inositol-1P-lipid. Biosynthesis of GPI anchors proceeds in three stages: (i) preassembly of a GPI precursor in the ER membrane, (ii) attachment of the GPI to the C-terminus of a newly synthesized protein in the lumen of the ER, and (iii) lipid remodeling and/or carbohydrate side-chain modifications in the ER and the Golgi. Defects of GPI anchor biosynthesis gene result in a genetic disorder, paroxysmal nocturnal hemoglobinuria.
No. of Genes in ADHDgene  4
Source Pathway by Database Search

Pathway related genes in ADHDgene (count: 4)

Literature-origin genes (count: 0)

Genes from other sources Help(count: 4)

Approved Symbol Approved Name Location Source
PIGW phosphatidylinositol glycan anchor biosynthesis, class W 17q21.1 Mapped by CNV
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 15q21-q22 Mapped by LD-proxy
PIGY phosphatidylinositol glycan anchor biosynthesis, class Y 4q22.1 Mapped by CNV
PIGL phosphatidylinositol glycan anchor biosynthesis, class L 17p12-p11.2 Mapped by significant region

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014