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KEGG Pathway Report
Basic Info
| ID | hsa04971 |
|---|---|
| Name | Gastric acid secretion |
| Description | Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetycholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+,K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and thereby H+ secretion into the stomach lumen. |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 12)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 12p11.23 | Mapped by LD-proxy; Mapped by literature SNP |
| SLC4A2 | solute carrier family 4, anion exchanger, member 2 (erythrocyte membrane protein band 3-like 1) | 7q35-q36 | Mapped by LD-proxy; Mapped by literature SNP |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 3p26.1 | Mapped by CNV |
| CA2 | carbonic anhydrase II | 8q22 | Mapped by CNV |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 4q26 | Mapped by CNV |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| CCKBR | cholecystokinin B receptor | 11p15.4 | Mapped by CNV; Mapped by PBA pathway |
| CHRM3 | cholinergic receptor, muscarinic 3 | 1q41-q44 | Mapped by CNV; Mapped by PBA pathway |
| KCNJ1 | potassium inwardly-rectifying channel, subfamily J, member 1 | 11q24 | Mapped by significant region |
| ADCY4 | adenylate cyclase 4 | 14q11.2 | Mapped by significant region |