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KEGG Pathway Report
Basic Info
| ID | hsa05210 |
|---|---|
| Name | Colorectal cancer |
| Description | Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes (TSG). Two major mechanisms of genomic instability have been identified in sporadic CRC progression. The first, known as chromosomal instability (CIN), results from a series of genetic changes that involve the activation of oncogenes such as K-ras and inactivation of TSG such as p53, DCC/Smad4, and APC. The second, known as microsatellite instability (MSI), results from inactivation of the DNA mismatch repair genes MLH1 and/or MSH2 by hypermethylation of their promoter, and secondary mutation of genes with coding microsatellites, such as transforming growth factor receptor II (TGF-RII) and BAX. Hereditary syndromes have germline mutations in specific genes (mutation in the tumour suppressor gene APC on chromosome 5q in FAP, mutated DNA mismatch repair genes in HNPCC). |
| No. of Genes in ADHDgene | 11 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 11)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| GSK3B | glycogen synthase kinase 3 beta | 3q13.3 | 1(1/0/0) |
Genes from other sources (count: 10)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| APC | adenomatous polyposis coli | 5q21-q22 | Mapped by LD-proxy; Mapped by PBA pathway |
| MAPK9 | mitogen-activated protein kinase 9 | 5q35 | Mapped by CNV |
| TGFBR1 | transforming growth factor, beta receptor 1 | 9q22 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CYCS | cytochrome c, somatic | 7p21.2 | Mapped by CNV; Mapped by significant region |