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KEGG Pathway Report
Basic Info
| ID | hsa05220 |
|---|---|
| Name | Chronic myeloid leukemia |
| Description | Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and other hematopoetic cell lineages are involved in the process of clonal proliferation and differentiation. On the cellular level, CML is associated with a specific chromosome abnormality, the t(9; 22) reciprocal translocation that forms the Philadelphia (Ph) chromosome. The Ph chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromosome 9 and the BCR (breakpoint cluster region) gene on chromosome 22. The BCR/ABL fusion gene encodes p210 BCR/ABL, an oncoprotein, which, unlike the normal p145 c-Abl, has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm. While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. Common secondary abnormalities include mutations in TP53, RB, and p16/INK4A, or overexpression of genes such as EVI1. Additional chromosome translocations are also observed,such as t(3;21)(q26;q22), which generates AML1-EVI1. |
| No. of Genes in ADHDgene | 12 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 12)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 12)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RELA | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | 11q13 | Mapped by significant region |
| TGFBR1 | transforming growth factor, beta receptor 1 | 9q22 | Mapped by significant region |
| PIK3R1 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 5q13.1 | Mapped by significant region |
| GAB2 | GRB2-associated binding protein 2 | 11q13.4-q13.5 | Mapped by significant region |
| CCND1 | cyclin D1 | 11q13 | Mapped by significant region |
| BAD | BCL2-associated agonist of cell death | 11q13.1 | Mapped by significant region |
| PIK3CG | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 7q22 | Mapped by CNV |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 11q23.3-qter | Mapped by significant region |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| CRKL | v-crk sarcoma virus CT10 oncogene homolog (avian)-like | 22q11.21 | Mapped by CNV |
| SHC3 | SHC (Src homology 2 domain containing) transforming protein 3 | 9q22.1 | Mapped by significant region |