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KEGG Pathway Report
Basic Info
| ID | hsa05143 |
|---|---|
| Name | African trypanosomiasis |
| Description | Trypanosoma brucei, the parasite responsible for African trypanosomiasis (sleeping sickness), are spread by the tsetse fly in sub-Saharan Africa. The parasites are able to pass through the blood-brain barrier and cause neurological damage by inducing cytokines like TNF alpha, IFN gamma, and IL1. These cytokines and other metabolites such as nitric oxide and somnogenic prostaglandin D2 disturb circadian rhythms in patients with African trypanosomiasis. |
| No. of Genes in ADHDgene | 8 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 8)
Literature-origin genes (count: 0)
Genes from other sources 
(count: 8)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| PRKCB | protein kinase C, beta | 16p12 | Mapped by significant region |
| IL12B | interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | 5q31.1-q33.1 | Mapped by significant region |
| APOA1 | apolipoprotein A-I | 11q23-q24 | Mapped by significant region |
| PLCB2 | phospholipase C, beta 2 | 15q15 | Mapped by PBA pathway |
| THOP1 | thimet oligopeptidase 1 | 19p13.3 | Mapped by LD-proxy |
| PLCB3 | phospholipase C, beta 3 (phosphatidylinositol-specific) | 11q13 | Mapped by significant region |
| IL18 | interleukin 18 (interferon-gamma-inducing factor) | 11q22.2-q22.3 | Mapped by significant region |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |