ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Ribases, M., 201222504457
Citation	Ribases M., Sanchez-Mora C., Ramos-Quiroga J. A., Bosch R., Gomez N., Nogueira M., Corrales M., Palomar G., Jacob C. P., Gross-Lesch S., Kreiker S., Reif A., Lesch K. P., Cormand B., Casas M. and Bayes M. (2012) "An association study of sequence variants in the forkhead box P2 (FOXP2) gene and adulthood attention-deficit/hyperactivity disorder in two European samples." Psychiatr Genet, 22(4): 155-60.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	1004 adult ADHD patients and 1061 controls
Predominant Ethnicity	Caucasian
Population	German an Spanish
Gender	Sixty-three percent of patients were men.
Age Group	Adults : The average age at assessment was 36.5 years (SD=14.8) for patients and 29.5 years (SD=12.0) for controls.

Detail Info

Summary	Our aim was to carry out an association study between FOXP2 and adulthood ADHD. We carried out a case-control association study in 643 adult ADHD patients and 619 controls from Germany and in 361 adult ADHD patients and 442 controls from Spain with 12 tagging single nucleotide polymorphisms covering the FOXP2 gene. RESULTS: The single-marker and multiple-marker analyses showed an association between FOXP2 and combined ADHD in the German cohort [rs12533005: P=0.0033; odds ratio=1.30 (1.09-1.56); rs12533005/rs1229761: P=4.1e-04; odds ratio=1.38 (1.15-1.66)]. These positive results, however, were not confirmed in the Spanish sample.
Total Sample	In total, 1004 adult ADHD patients (68.6% combined, 25.3% inattentive, and 6.1% hyperactive-impulsive) and 1061 controls of Caucasian origin from Germany and Spain were recruited. Sixty-three percent of patients were men. The average age at assessment was 36.5 years (SD=14.8) for patients and 29.5 years (SD=12.0) for controls. The control sample matched for sex with the ADHD group, and in most of them DSM-IV ADHD symptomatology was excluded (except for 44% of the German sample).
Sample Collection	In total, 1004 adult ADHD patients (68.6% combined, 25.3% inattentive, and 6.1% hyperactive-impulsive) and 1061 controls of Caucasian origin from Germany and Spain were recruited.
Diagnosis Description	The ADHD diagnosis was made on the basis of the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV) Axis I and Axis II Disorders (SCID-I and SCID-II) and the Conners' Adult ADHD Diagnostic Interview for DSM-IV (CADDID).
Technique	All SNPs were genotyped using the SNPlex platform.
Analysis Method	The analysis of Hardy-Weinberg equilibrium (P<0.05) and the comparison of genotype and allele frequencies under a log-additive model were carried out using the SNPassoc R package.
Result Description	The single-marker and multiple-marker analyses showed an association between FOXP2 and combined ADHD in the German cohort [rs12533005: P=0.0033; odds ratio=1.30 (1.09-1.56); rs12533005/rs1229761: P=4.1e-04; odds ratio=1.38 (1.15-1.66)]. These positive results, however, were not confirmed in the Spanish sample. Although these preliminary findings provide a tentative evidence for the contribution of FOXP2 to ADHD and suggest common genetic factors for this psychiatric disorder and learning disabilities, they should be interpreted with caution. Further studies in larger samples are needed to clarify the role of this transcription factor in ADHD.

SNPs reported by this study (count: 12)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs10228350			P-value=0.116 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.066, OR (95% CI)=- in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	No significant association was found. No significant association was found.	Non-significant
rs12533005			P-value=0.034, OR (95% CI)=1.19 (1.01-0.58) in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.0033, OR (95% CI)=1.30 (1.09-1.56) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). In contrast, a nominal association was found in the German sample. The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs4727799			P-value=0.141 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.015, OR (95% CI)=1.26 (1.04-1.51) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs10486026			P-value=0.211 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.375, OR (95% CI)=- in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	No significant association was found. No significant association was found.	Non-significant
rs10268637			P-value=0.114 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.046, OR (95% CI)=1.20 (1.00-1.44) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs10255943			P-value=0.199 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.035, OR (95% CI)=1.23 (1.01-1.51) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs936146			P-value=0.025, OR (95% CI)=1.20 (1.02-1.41) in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.02, OR (95% CI)=1.23 (1.03-1.47) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). In contrast, a nominal association was found in the German sample. The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs10953766			P-value=0.47 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.16, OR (95% CI)=- in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	No significant association was found. No significant association was found.	Non-significant
rs17137124			P-value=0.056 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.02, OR (95% CI)=1.23 (1.03-1.47) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs1229761			P-value=0.1 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.0065, OR (95% CI)=1.28 (1.07-1.54) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant
rs7782412			P-value=0.327 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.272, OR (95% CI)=- in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	No significant association was found. No significant association was found.	Non-significant
rs7799652			P-value=0.232 in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.197, OR (95% CI)=- in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany	No significant association was found. No significant association was found.	Non-significant

Genes reported by this study (count: 1)