ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs936146 dbSNP Ensembl
Location	chr7:114294405(Fwd)
Variant Alleles	G/C
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; intron_variant; NMD_transcript_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000360232; ENST00000390668; ENST00000607845) intron_variant(ENST00000350908; ENST00000393489; ENST00000393491; ENST00000393494; ENST00000393498; ENST00000393500; ENST00000403559; ENST00000408937; ENST00000412402; ENST00000441290) NMD_transcript_variant(ENST00000412402; ENST00000441290)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases, M., 2012			P-value=0.025, OR (95% CI)=1.20 (1.02-1.41) in 643 adult att...... P-value=0.025, OR (95% CI)=1.20 (1.02-1.41) in 643 adult attention-deficit/hyperactivity disorder patients and and 619 unrelated controls from Germany; P-value=0.02, OR (95% CI)=1.23 (1.03-1.47) in 431 combined attention-deficit/hyperactivity disorder patients and 619 unrelated controls from Germany More...	The single-marker study under a log additive model showed no...... The single-marker study under a log additive model showed no evidence of an association between FOXP2 and adulthood ADHD when the overall sample or the combined and inattentive types of ADHD from Spain were considered (data not shown). In contrast, a nominal association was found in the German sample. The SNP reached statistical significance in the German combinedtype ADHD group. More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
FOXP2	forkhead box P2	7q31	1(1/0/0)

Genes from other sources (count: 0)

SNPs in LD with rs936146 (count: 60) View in gBrowse (chr7:114291052..114428727 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 60)

rs_ID	Functional Annotation	r²[population]
rs601926		0.857[CHB]; 0.847[CHD]
rs1456021	intron_variant; NMD_transcript_variant	0.857[CHB]
rs4730637	intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.897[JPT]
rs12705978	downstream_gene_variant	1.0[CEU]; 0.857[CHB]
rs12705971	downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 0.95[TSI]; 1.0[CHB]; 1.0[CHD]; 0.897[JPT]; 0.897[MEX]
rs1563408	intron_variant; NMD_transcript_variant	1.0[CEU]
rs2396765	3_prime_UTR_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.895[JPT]
rs12154339	downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.888[JPT]
rs12705984	downstream_gene_variant	0.877[CEU]
rs12670585	intron_variant; NMD_transcript_variant; upstream_gene_variant	0.85[CHB]; 0.847[CHD]
rs2045293		0.852[CEU]; 0.857[CHB]
rs17504461		0.841[CHD]
rs4727805		0.819[CHB]
rs4730641		0.857[CHB]; 0.882[CHD]
rs12705975	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.857[CHB]
rs12705973	downstream_gene_variant; intron_variant; NMD_transcript_variant	0.961[CEU]; 0.952[TSI]; 1.0[CHB]; 0.959[CHD]; 0.897[JPT]; 0.902[MEX]
rs1378770		0.857[CHB]; 0.882[CHD]
rs1979089		0.842[CHB]
rs1378767		0.871[CEU]
rs2124474		0.857[CHB]
rs12705974	intron_variant; NMD_transcript_variant	1.0[CEU]
rs681914		0.842[CHD]
rs1005958	intron_variant; NMD_transcript_variant	1.0[CEU]
rs17291908	intron_variant; NMD_transcript_variant	1.0[CEU]
rs12705985	downstream_gene_variant	0.852[CEU]; 0.857[CHB]
rs4727801		0.857[CHB]; 0.882[CHD]
rs12705977	3_prime_UTR_variant; downstream_gene_variant	1.0[CEU]; 0.857[CHB]
rs13246064		0.852[CEU]; 0.857[CHB]
rs12705980	downstream_gene_variant	1.0[CEU]; 0.857[CHB]
rs12705981	downstream_gene_variant	1.0[CEU]; 0.849[CHB]
rs675236		0.834[CHD]
rs12705982	downstream_gene_variant	1.0[CEU]; 0.952[TSI]; 0.857[CHB]; 1.0[CHD]; 0.902[MEX]
rs1456020	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.857[CHB]
rs684253		0.857[CHB]; 0.847[CHD]
rs12705970	3_prime_UTR_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.897[JPT]
rs12154391	intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.896[JPT]
rs10500039		0.852[CEU]; 0.857[CHB]
rs613499		0.857[CHB]; 0.847[CHD]
rs1350134	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.849[CHB]
rs1378772	3_prime_UTR_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.897[JPT]
rs983483		0.857[CHB]; 0.847[CHD]
rs2396766	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.952[TSI]; 0.857[CHB]; 0.888[CHD]; 0.902[MEX]
rs625726		0.857[CHB]
rs4730643		0.857[CHB]; 0.882[CHD]
rs4236599	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.857[CHB]
rs17292989		0.857[CHB]
rs12671330	downstream_gene_variant	1.0[CEU]; 0.952[TSI]; 0.857[CHB]; 1.0[CHD]; 0.902[MEX]
rs1005959	intron_variant; NMD_transcript_variant	1.0[CHB]; 0.821[JPT]
rs10250103	downstream_gene_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 1.0[CHB]; 0.897[JPT]
rs1378771	3_prime_UTR_variant; intron_variant; NMD_transcript_variant	1.0[CEU]; 0.952[TSI]; 1.0[CHB]; 1.0[CHD]; 0.897[JPT]; 0.901[MEX]
rs13312596		0.852[CEU]; 0.857[CHB]
rs12705987		0.852[CEU]; 0.857[CHB]; 0.882[CHD]
rs647055		0.857[CHB]; 0.847[CHD]
rs1869839		0.857[CHB]; 0.882[CHD]
rs12705986		0.852[CEU]; 0.849[CHB]
rs13233601		0.85[CHB]
rs13222712		0.84[CEU]; 0.841[CHB]
rs12705979	downstream_gene_variant	1.0[CEU]; 0.885[TSI]
rs13226763	intron_variant; NMD_transcript_variant	1.0[CEU]; 0.857[CHB]
rs1840661		0.8[CEU]; 0.842[CHB]