ADHDgene Database

SNP Report

Basic Info

Name	rs6327 dbSNP Ensembl
Location	Chr1:115829986(Fwd)
Variant Alleles	C/T/-
Ancestral Allele	C
Functional Annotation	feature_truncation; intron_variant; nc_transcript_variant.
Consequence to Transcript	feature_truncation(ENST00000369512; ENST00000425449; LRG_260_t1) intron_variant(ENST00000369512; ENST00000425449; LRG_260_t1) nc_transcript_variant(ENST00000425449)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases M, 2008			genotypic P-value=0.036; genotypic P-value=0.44 in dominant ...... genotypic P-value=0.036; genotypic P-value=0.44 in dominant model; genotypic P-value=0.04, OR=1.49 (1.02-2.16) in recessive model; allelic P-value=0.48 in Adults More...	provided evidence of association with adulthood ADHD provided evidence of association with adulthood ADHD	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
NGF	nerve growth factor (beta polypeptide)	1p13.1	2(2/0/0)

SNPs in LD with rs6327 (count: 5) View in gBrowse (chr1:115809848..115830631 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.


rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]
rs6330	intron_variant; missense_variant; nc_transcript_variant	1(0/1/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.95[CHD]; 1.0[GIH]; 1.0[JPT]; 0.955[LWK]; 1.0[MEX]; 0.912[MKK]; 1.0[TSI]; 1.0[YRI]

rs_ID	Functional Annotation	r²[population]
rs2982742		0.821[CEU]
rs12759401		0.88[CEU]
rs2747063	intron_variant; nc_transcript_variant	0.915[CEU]; 0.934[JPT]
rs2068797	upstream_gene_variant	0.821[CEU]