ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs4689440 dbSNP Ensembl
Location	Chr4:6421406(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant.
Consequence to Transcript	intron_variant(ENST00000314348; ENST00000507294; ENST00000507028; ENST00000515571; ENST00000382599; ENST00000506140) nc_transcript_variant(ENST00000314348; ENST00000507028)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Jacob, C., 2012		G	P-value=0.0464, OR=1.2395% CI=(1.00-1.51) in the adult case-...... P-value=0.0464, OR=1.2395% CI=(1.00-1.51) in the adult case-control sample; FBAT P-value=0.2265 in the families with ADHD children More...	In the adult sample, rs4689440 showed nominally significant ...... In the adult sample, rs4689440 showed nominally significant association with disease. More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
PPP2R2C	protein phosphatase 2, regulatory subunit B, gamma	4p16.1	1(1/0/0)

Genes from other sources (count: 0)

SNPs in LD with rs4689440 (count: 22) View in gBrowse (chr4:6414212..6444182 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 22)

rs_ID	Functional Annotation	r²[population]
rs10213247	intron_variant; nc_transcript_variant	0.861[CEU]; 1.0[CHB]; 1.0[JPT]
rs12507333	intron_variant; nc_transcript_variant	0.956[CEU]
rs4689000	intron_variant; nc_transcript_variant	1.0[CEU]; 0.928[CHB]; 0.952[CHD]; 0.946[GIH]; 0.924[JPT]; 0.867[MEX]; 1.0[TSI]
rs17778826	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.872[GIH]; 0.867[MEX]
rs11734695	intron_variant; nc_transcript_variant; upstream_gene_variant	0.914[CEU]; 0.824[MEX]
rs9991896	intron_variant; nc_transcript_variant	0.83[CEU]
rs4689002	intron_variant; nc_transcript_variant	0.913[CEU]
rs11724359	intron_variant; nc_transcript_variant	0.897[CEU]; 1.0[CHB]; 1.0[JPT]
rs4689443	intron_variant; nc_transcript_variant	0.875[CEU]; 0.826[MEX]
rs11724762	intron_variant; nc_transcript_variant	0.838[CEU]; 0.864[MEX]
rs13434456	intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.946[GIH]; 1.0[JPT]; 0.91[MEX]; 1.0[TSI]
rs10213596	intron_variant; nc_transcript_variant	0.914[CEU]; 1.0[CHB]; 1.0[JPT]
rs744699	intron_variant; nc_transcript_variant	0.875[CEU]
rs10213664	intron_variant; nc_transcript_variant	0.913[CEU]; 1.0[CHB]; 1.0[JPT]
rs11726287	intron_variant; nc_transcript_variant; upstream_gene_variant	0.914[CEU]; 0.826[MEX]
rs11724328	intron_variant; nc_transcript_variant	0.914[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.91[MEX]; 0.862[TSI]
rs9992005	intron_variant; nc_transcript_variant	0.913[CEU]; 1.0[CHB]; 1.0[JPT]
rs4334819	intron_variant; nc_transcript_variant	0.956[CEU]; 0.817[GIH]; 1.0[MEX]
rs4522940	intron_variant; nc_transcript_variant	0.838[CEU]
rs878281	intron_variant; nc_transcript_variant	0.911[CEU]; 1.0[MEX]; 0.857[TSI]
rs10015220	intron_variant; nc_transcript_variant	0.912[CEU]; 1.0[CHB]; 1.0[JPT]
rs878283	intron_variant; nc_transcript_variant	0.953[CEU]