ADHDgene Database

SNP Report

Basic Info

Name	rs2269272 dbSNP Ensembl
Location	chr5:36687856(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000265113; ENST00000381918) downstream_gene_variant(ENST00000506178) intron_variant(ENST00000510740) nc_transcript_variant(ENST00000510740)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Turic D, 2005(a)	C/T		P-value=0.08 for pooled genotyping; allelic TRANSMIT P-value...... P-value=0.08 for pooled genotyping; allelic TRANSMIT P-value=0.007, X²=8.54 More...	an excess of transmissions of T allele was confirmed an excess of transmissions of T allele was confirmed	Significant
Laurin N, 2008(a)	C/T		P-value=0.963 in the catergorical analysis, P-value>0.05 in ...... P-value=0.963 in the catergorical analysis, P-value>0.05 in the quantitative analysis More...	no significant evidence of association no significant evidence of association	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	5p13	2(1/1/0)

SNPs in LD with rs2269272 (count: 4) View in gBrowse (chr5:36684550..36696578 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs3776586	intron_variant; nc_transcript_variant	0.945[CEU]; 0.856[TSI]; 1.0[CHB]; 0.89[CHD]; 0.943[JPT]; 0.941[GIH]; 0.921[LWK]; 1.0[MEX]
rs12654484	intron_variant; nc_transcript_variant	1.0[YRI]
rs4869487	downstream_gene_variant; intron_variant; nc_transcript_variant	0.887[CEU]; 0.928[TSI]; 0.944[CHB]; 0.97[CHD]; 0.941[JPT]; 0.959[LWK]; 0.871[MEX]; 1.0[YRI]
rs12654391	intron_variant; nc_transcript_variant	0.958[LWK]; 1.0[YRI]