ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1352250 dbSNP Ensembl
Location	chr12:72397784(Fwd)
Variant Alleles	A/G
Ancestral Allele	G
Functional Annotation	intron_variant.
Consequence to Transcript	intron_variant(ENST00000333850)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Oades RD, 2008			P-value=0.011413; FDR P-value=0.06598 for cognitive impulsiv...... P-value=0.011413; FDR P-value=0.06598 for cognitive impulsivity More...	attained nominal significance for an association with cognit...... attained nominal significance for an association with cognitive impulsivity More...	Significant
Johansson S, 2010			logistic regression P-value=0.33, OR=1.09 logistic regression P-value=0.33, OR=1.09	no significant association no significant association	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	11(8/3/0)

Genes from other sources (count: 0)

SNPs in LD with rs1352250 (count: 35) View in gBrowse (chr12:72346800..72410079 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 35)

rs_ID	Functional Annotation	r²[population]
rs4760750	intron_variant	0.853[JPT]
rs11179049	intron_variant	0.8[CHB]
rs9325202	intron_variant	0.88[CEU]; 0.859[YRI]
rs4760816	intron_variant	0.919[CEU]; 0.86[JPT]
rs1843811	intron_variant	0.807[CEU]; 0.867[JPT]
rs12319219	intron_variant	0.91[JPT]
rs10879345	intron_variant; nc_transcript_variant	0.919[CEU]
rs4641528	intron_variant	0.919[CEU]; 0.817[JPT]; 0.849[YRI]
rs7969114	intron_variant	0.831[CEU]; 0.857[JPT]
rs7309686	intron_variant	0.837[CEU]; 0.845[JPT]
rs7979770	intron_variant	0.844[CEU]; 0.837[CHB]; 0.826[JPT]; 0.93[YRI]
rs11179039	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs2368049	intron_variant	0.829[CHB]; 0.927[YRI]
rs4760755	intron_variant	0.919[CEU]; 0.817[JPT]; 0.849[YRI]
rs7963720	intron_variant	0.919[CEU]; 0.86[JPT]; 0.816[YRI]
rs10879346	intron_variant; nc_transcript_variant	0.847[CEU]; 0.859[YRI]
rs1532008	intron_variant	0.837[CHB]; 0.826[JPT]; 0.931[YRI]
rs4760817	intron_variant	0.919[CEU]; 0.86[JPT]; 0.849[YRI]
rs11834114	intron_variant	0.817[JPT]
rs10879351	intron_variant	1.0[CEU]; 1.0[CHB]; 0.953[JPT]; 1.0[YRI]
rs1352251	intron_variant	0.871[JPT]; 0.931[YRI]
rs4760754	intron_variant	0.919[CEU]; 0.817[JPT]; 0.849[YRI]
rs11179033	intron_variant	0.817[JPT]
rs10879350	intron_variant	0.817[JPT]
rs10748190	intron_variant	0.882[CEU]; 0.87[YRI]
rs11179050	intron_variant	0.826[CHB]
rs6582073	intron_variant	0.919[CEU]; 0.86[JPT]
rs11834097	intron_variant	0.826[JPT]
rs12322900	intron_variant; nc_transcript_variant	0.844[CEU]; 0.862[YRI]
rs7967686	intron_variant	0.827[CEU]; 0.8[CHB]; 0.927[YRI]
rs3903502	intron_variant	0.88[CEU]
rs6582077	intron_variant	0.917[CEU]; 0.817[JPT]
rs12229394	intron_variant	0.817[JPT]
rs11179023	intron_variant	0.816[JPT]
rs2171363	downstream_gene_variant; intron_variant	0.919[CEU]