Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa04260 |
|---|---|
| Name | Cardiac muscle contraction |
| Description | Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR. |
| No. of Genes in ADHDgene | 19 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 19)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| COX7B2 | cytochrome c oxidase subunit VIIb2 | 4p12 | 1(0/1/0) |
| CACNA1C | calcium channel, voltage-dependent, L type, alpha 1C subunit | 12p13.3 | 1(0/1/0) |
Genes from other sources (count: 17)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CACNG5 | calcium channel, voltage-dependent, gamma subunit 5 | 17q24 | Mapped by PBA pathway |
| RYR2 | ryanodine receptor 2 (cardiac) | 1q43 | Mapped by CNV; Mapped by PBA pathway |
| COX8A | cytochrome c oxidase subunit VIIIA (ubiquitous) | 11q12-q13 | Mapped by significant region |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | 2q22-q23 | Mapped by PBA pathway |
| UQCRC2 | ubiquinol-cytochrome c reductase core protein II | 16p12 | Mapped by CNV; Mapped by significant region |
| CACNG1 | calcium channel, voltage-dependent, gamma subunit 1 | 17q24 | Mapped by PBA pathway |
| CACNG2 | calcium channel, voltage-dependent, gamma subunit 2 | 22q13.1 | Mapped by PBA pathway |
| CACNG4 | calcium channel, voltage-dependent, gamma subunit 4 | 17q24 | Mapped by PBA pathway |
| FXYD2 | FXYD domain containing ion transport regulator 2 | 11q23 | Mapped by significant region |
| CACNA1F | calcium channel, voltage-dependent, L type, alpha 1F subunit | Xp11.23 | Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP |
| CACNB1 | calcium channel, voltage-dependent, beta 1 subunit | 17q21-q22 | Mapped by PBA pathway |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | 16q24.1 | Mapped by significant region |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 7q21-q22 | Mapped by PBA pathway |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | 12q13 | Mapped by PBA pathway |
| CACNB2 | calcium channel, voltage-dependent, beta 2 subunit | 10p12 | Mapped by PBA pathway |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 3p14.3 | Mapped by PBA pathway |
| CACNA1S | calcium channel, voltage-dependent, L type, alpha 1S subunit | 1q32 | Mapped by PBA pathway |