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KEGG Pathway Report
Basic Info
| ID | hsa04350 |
|---|---|
| Name | TGF-beta signaling pathway |
| Description | The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins. |
| No. of Genes in ADHDgene | 10 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 10)
Literature-origin genes (count: 2)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 2p25 | 1(0/1/0) |
| BMPR1B | bone morphogenetic protein receptor, type IB | 4q23-q24 | 1(0/0/1) |
Genes from other sources (count: 8)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| RPS6KB2 | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | 11q13.1 | Mapped by significant region |
| TGFBR1 | transforming growth factor, beta receptor 1 | 9q22 | Mapped by significant region |
| PPP2R1B | protein phosphatase 2, regulatory subunit A, beta | 11q23.1 | Mapped by significant region |
| MAPK3 | mitogen-activated protein kinase 3 | 16p11.2 | Mapped by CNV |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 2p22-p21 | Mapped by CNV |
| E2F5 | E2F transcription factor 5, p130-binding | 8q21.2 | Mapped by CNV |
| MAPK1 | mitogen-activated protein kinase 1 | 22q11.2 | Mapped by LD-proxy |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 2p24 | Mapped by significant region |