Hot Results
- Quick Search
- Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
- Data Summary
KEGG Pathway Report
Basic Info
| ID | hsa04672 |
|---|---|
| Name | Intestinal immune network for IgA production |
| Description | The intestine is the largest lymphoid tissue in the body. One striking feature of intestinal immunity is its ability to generate great amounts of noninflammatory immunoglobulin A (IgA) antibodies that serve as the first line of defense against microorganisms. The basic map of IgA production includes induction of mucosal B cells in the Peyer's patches, circulation through the bloodstream and homing to intestinal mucosa of IgA-commited plasma cells, and local antibody production for export across the intestinal membranes. Multiple cytokines, including TGF-{beta}, IL-10, IL-4, IL-5, and IL-6, are required to promote IgA class switching and terminal differentiation process of the B cells. Secreted IgA promotes immune exclusion by entrapping dietary antigens and microorganisms in the mucus and functions for neutralization of toxins and pathogenic microbes. |
| No. of Genes in ADHDgene | 5 |
| Source | Pathway by Database Search |
Pathway related genes in ADHDgene (count: 5)
Literature-origin genes (count: 1)
| Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend)  |
|---|---|---|---|
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | 6p21.3 | 2(1/1/0) |
Genes from other sources (count: 4)
| Approved Symbol | Approved Name | Location | Source |
|---|---|---|---|
| CCL27 | chemokine (C-C motif) ligand 27 | 9p13 | Mapped by LD-proxy |
| TNFRSF13B | tumor necrosis factor receptor superfamily, member 13B | 17p11.2 | Mapped by significant region |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 10q11.1 | Mapped by PBA pathway |
| IL6 | interleukin 6 (interferon, beta 2) | 7p21-p15 | Mapped by significant region |